重组人IL-1β、IL-6对小鼠体外早期胚胎发育的影响  

IN Vitro Effects of rIL-1β、rIL-6 on Early Embryo Development in Mice

作　　者：汪玉宝[1] 何志英[1] 顾敦瑜[1] 冯缵冲[1] 

机构地区：[1]上海市计划生育科学研究所,上海200032

出　　处：《上海实验动物科学》1996年第1期18-20,共3页Shanghai Laboratory Animal Science

摘　　要：研究了重组人白细胞介素(rIL-1β、rIL-6)对ICR小鼠体外早期胚胎发育的影响。结果表明:(1)培养液中rIL-1β浓度为4、10、100IU/ml时,对胚胎的发育无明显影响;(2)rIL-6在浓度4、10IU/ml时,对胚胎的发育无明显影响;当浓度为100IU/ml时,则对胚胎的发育有明显抑制作用及毒性作用。结果提示:IL-6在高浓度时对胚胎具有直接毒性作用。The purpose of the study was to investigate whether the human recombinant interleukins(rIL-1β、rIL-6) had a direct action on the development of early embryos. The experiments were done in ICR mouse. The results revealed:(1)rIL-1β had no effects on the early embryogenesis of mouse in vitro at the concentration of 4,10 and 100IU/ml respectively. (2)the development of embryos was significantly suppressed by adding the rIL-6 to the media at a concentration of 100IU/ml, at the same time,the embryotoxcity was clearly observed. These results suggest that IL-6 may have the effect of direct embryo toxcity at a high concentration.

关 键 词：重组 白细胞介素 胚胎发育 小鼠 动物实验 

分 类 号：R321[医药卫生—人体解剖和组织胚胎学]