红细胞4．1蛋白与血型糖蛋白C／D结合位点研究进展  

The Progress in Binding Sites of Protein 4. 1 on Glycophorins C and D of Human Erythrocyte

作　　者：焦新福[1] 舒沪英[1] 

机构地区：[1]武汉同济医科大学附属同济医院

出　　处：《生物化学与生物物理进展》1996年第2期125-126,共2页Progress In Biochemistry and Biophysics

摘　　要：红细胞膜骨架与脂双层间存在着相互作用，其中带４．１蛋白与血型糖蛋白Ｃ／Ｄ间的相互作用对维持正常红细胞的形态和机械稳定性起着重要作用，研究表明，带４．１蛋白在血型糖蛋白Ｃ、Ｄ上的结合位点分别位于血型糖蛋白Ｃ的第８２～９８位氨基酸残基和血型糖蛋白Ｄ的第６１～７７位氨基酸残基．The human erythrocyte membraneskeleton protein 4. 1 interacts with glycophorin C/D (GPC/D ). This interaction particularly determines the shape and the mechanical properties of the red cell. A number of workers have provided evidence for the interaction. Recent publication has reported that GPC/D provide major membrane binding sites for protein 4. 1 in normal erythrocyte, and the sites are located on amino acid residues 82～98 of GPC and 61～77of GPD.

关 键 词：红细胞 带4.1蛋白 血型糖蛋白 结合位点 

分 类 号：R329.26[医药卫生—人体解剖和组织胚胎学]