压力超负荷诱导左心室原癌基因c－fos的表达  

EXPRESSION OF C-FOS mRNA INDUCED BY PRESSURE OVERLOAD IN THE LEFT VENTRICLE

作　　者：谭定定[1] 钟春宁[1] 陈伟红[1] 潘敬运[1] 胡本荣[1] 

机构地区：[1]中山医科大学受体实验室,分子生物学实验室

出　　处：《生理学报》1996年第1期65-69,共5页Acta Physiologica Sinica

基　　金：国家自然科学基金;中华医学基金

摘　　要：本实验在腹主动脉缩窄的大鼠上，探讨压力超负荷对左心室原癌基因ｃ－ｆｏｓ的表达。观察到压力超负荷可引起ｃ－ｆｏｓ的明显表达，这种作用可被巯甲丙脯酸显著减弱。同时，我们检测到压力超负荷时左心室血管紧张素原的表达也增强。这些结果提示压力超负荷诱导的左心室ｃ－ｆｏｓｍＲＮＡ的表达有血管紧张素Ⅱ的参与。In the present Study the effect of pressure overload on the expression of protooncogene c-fos in the left ventricle was investigated in rats with abdominal aortu constriction. It was found that a remarkable expression of c-fos was induced by pressure overload and the expression was greatly attenuated by angiotensin converting enzyme inhibitor captopril. In the pressure overload group the angiotensinogen mRNA level wasfound increased. The above results suggest that angiotensin Ⅱ is involved in the expression of c-fos due to pressure overload.

关 键 词：压力超负荷 C-FOS 原癌基因 心肌肥厚 

分 类 号：R542.202[医药卫生—心血管疾病]