酪氨酸对大鼠子宫胞浆雌、孕激素受体的影响  

EFFECT OF L-TYR ON THE UTERINE CYTOSOL ESTRADIOL AND PROGESTERONE RECEPTORS IN RAT

作　　者：王妮[1] 付小锁[1] 程治平[1] 

机构地区：[1]哈尔滨医科大学生理教研室,中国科学院动物研究所生殖生物学国家重点实验室

出　　处：《生理学报》1996年第1期83-88,共6页Acta Physiologica Sinica

摘　　要：采用放射受体分析法，测定了动情周期不同阶段及去卵巢大鼠子宫胞浆雌二醇和孕酮受体含量，并观察了子宫腔内注射酪、丝、苏三种氨基酸对子宫胞浆雌。醇、孕酮受体含量的影响。结果表明：（１）Ｌ－酪氨酸对动情前期、动情期、间情期大鼠子宫胞浆雌二醇和孕酮受体都具有明显的降低作用。（２）Ｌ－酪氨酸也降低去卵巢大鼠子宫胞浆雌二醇和孕酮含量，即这一作用不是通过影响卵巢激素分泌实现的。（３）Ｌ－苏氨酸仅可降低动情期和间情期大鼠子宫胞浆孕酮受体含量，而对相应周期雌二醇受体没有明显作用。（４）Ｌ－丝氨酸和Ｌ－苏氨酸对去卵巢大鼠子宫胞浆雌二醇和孕酮受体均无影响。The effect of L-TYR on rat uterine cytosol estradiol and progesterone receptor contents was studied. The rats were divided into 4 groups: proestrus, estrus, metestrus anddiestrus. One horn of each uterus was injected with L-TYR (2 mmol/L, 0. 1 ml),while the other with 0. 1 ml 0. 9% NaCl serving as control. The mole concentration ofreceptor was calculated with RRA and cytosol receptor content was expressed as fmoi/mg protein. It was shown that L-TYR decreased significantly the uterine estradiol and progesterone receptors in proestrus, estrus and diestrus phases of the estrus cycle, but withouteffect on metestrus. This was most probably due to competitive combination of TYRwith some functional groups of the estradiol receptor because of similar chemical conformation of TYR to estradiol.Threonine could also decrease, to some extent, the uterine cytosol progesterone receptor content at estrus and dioestrus phases. Serine had no effect on the contents of uterine cytosol either estradiol or progeserone receptor in normal and ovariectomizedrats.The present observation indicates that L-TYR appears to affect the synthesis of thecytosol estradiol and progesterone receptor in the rat uterus independent, however, ofendogenous ovarian sex hormones, since the effect is still present in the ovariectomizedanimals.

关 键 词：酪氨酸 雌二醇受体 孕酮受体 子宫 生殖生理 

分 类 号：R339.22[医药卫生—人体生理学]