阴道微生态平衡在细菌性阴道病治疗中的意义  

Significance of vaginal microecological balance for therapy of bacterial vaginosis

作　　者：李卫平[1] 宋磊[1] 罗艳萍[2] 袁艺[1] 

机构地区：[1]解放军总医院妇产科,北京100853 [2]解放军总医院微生物科,北京100853

出　　处：《军医进修学院学报》2006年第3期187-189,共3页Academic Journal of Pla Postgraduate Medical School

摘　　要：目的:研究通过阴道内微生态平衡状态的维持对于治疗细菌性阴道病的价值。方法:根据Amsel标准确诊的细菌性阴道病患者32例(其中2例患者失访)随机分为4个实验组:单用定菌生组,联合组,序贯组,对照组。结果:停药3d后4组患者的临床症状、实验室检查结果均无显著性差异(P(0.05)。停药1个月后组1、2、4比实验组3患者的乳酸杆菌计数明显增加,在统计学上有显著性差异(P=0.0005),而其他无显著性差异(P(0.05)。结论:①阴道乳酸杆菌数量的降低与细菌性阴道病的初发及复发有明显相关性:在细菌性阴道病初发或复发患者阴道乳酸杆菌数量明显降低(在本研究中患病者阴道乳酸杆菌数量小于30个/1000倍视野)。②细菌性阴道病治疗方法的选择:阴道内单用定菌生10d、定菌生联合甲硝唑10d及单用甲硝唑10d的治疗方法均为效果较好的选择;而先用甲硝唑5d再用定菌生5d的序贯疗法不可取。③维持阴道微生态平衡对于治疗细菌性阴道病有较高价值。Objective： To study the value of the maintenance of the state of endovaginal microecological balance to therapy the bacterial vaginosis. Methods：Based on the standard of Amsel, 32 patients （among these patients 2 were losed）who were diagnosed for bacterial vaginosis were divided into 4 groups according to the section-random project： Lactobacilli capsule singly, lactobacilli capsule associated with metronidazole, first Lactobacilli capsule then metronidazole. Results：All patients of the 4 groups will be re-examinated respectively after withdrawal 3days and there is no significantly difference（ P 〉 0.05 ）among their clinical symptoms and laboratory examination. Lactobacilli Counting in group 1, 2, 4 is more than in group 3 after withdrawal 1 month and It is significantly different（ P =0.0005）acorroding to statistics. There are no significantly difference （P 〉 0.05 ）among the other items of laboratory examination and clinical symptoms （ P 〉 0.05 ）. Conclusions： （ 1 ） There is direct correlation between the reduction of the quantity of vaginal Lactobacilli and the occurrence and reoccurence of bacterial vaginosis. （2） To treat bacterial vaginosis the method of therapeutics in the group 1,2 and 4 is better than the one in group 3. （3） To maintain the microecological balance of vaginosis is valuable for treating bacterial vaginosis.

关 键 词：酸碱平衡 阴道病 细菌性 甲硝唑 乳杆菌 嗜酸 

分 类 号：R711.31[医药卫生—妇产科学]