Endostation在病理性瘢痕中的表达  

The expression of endostation in pathopysiological scar

作　　者：沈为民[1] 罗东升[1] 果磊[1] 

机构地区：[1]重庆医科大学附属第一医院整形美容科,重庆400016

出　　处：《中国实用美容整形外科杂志》2006年第3期236-238,共3页

摘　　要：目的探讨血管生成抑制因子在瘢痕的发生、发展中的作用和意义。方法选择临床上不同病理分类的瘢痕组织,以正常皮肤为对照,应用免疫组化法,观察瘢痕内血管生成抑制因子的表达情况和分布特征。结果血管生成抑制因子阳性颗粒主要位于表皮角朊细胞胞浆。增生性瘢痕组和瘢痕疙瘩组中,血管生成抑制因子的表达水平显著增强,而非增生性瘢痕组和正常皮肤组中,血管生成抑制因子表达弱阳性或阴性。结论血管生成抑制因子在病理性瘢痕的发生、发展过程中,具有重要作用。Objective to explore the effect and significance of endostatin in the formation and development of scars. Methods Different stages and different pathological types of scars were selected, which were compared with normal skin. The expression and distribution of endostatin in the scars were observed with SP immunohistochemical method. Results It is found that the endostatin positive staining mainly located in plasm of keratinocytes. Higher expression of endostatin were detected in hypertrophic scars and keloids. On the contrary, in non - hypertrophic scar and normal skin, the endostatin expression were at extremely low level.Conclusions Endostatin acts as an important factor in the occurence and development of scars.

关 键 词：血管生成抑制因子 血管生长因子 瘢痕 

分 类 号：R622[医药卫生—整形外科]