理中汤配方颗粒与汤剂的药效学比较  

Study on Pharmacodynamics of Compatible Granule and Traditional Decoction of Lizhongtang

作　　者：胡昌江[1] 李兴华[1] 杨婷[1] 吴平[1] 李兴迎[1] 

机构地区：[1]成都中医药大学药学院,四川成都610075

出　　处：《中国药业》2006年第8期5-6,共2页China Pharmaceuticals

基　　金：国家"十五"重大科技专项;项目编号:2001BA701A40-1

摘　　要：目的进行理中汤配方颗粒与汤剂的药效学比较。方法从影响脾虚小鼠小肠的推进运动、番泻叶所致的小鼠泄泻和正常小鼠的胃排空3个方面考察理中汤配方颗粒与汤剂药理作用的差异。结果理中汤配方颗粒与汤剂对这3个方面均有抑制作用。同剂量的配方颗粒与汤剂的抑制小肠推进运动和止泻作用无显著性差别,而抑制胃排空的作用配方颗粒强于汤剂。结论理中汤配方颗粒保留和部分增强了汤剂的药理作用。Objective To compare differences of pharmacodynamics from compatible granule and traditional decoction of Lizhongtang. Methods To conducte the intestine peristalsis test on mouse＇s model of spleen weak by oral administration of Radix et Rhizoma Rhei, lax inhibiting test on mouse＇s model of lax by oral administration of Foliun Sennae, and gastric emptying test on normal mouses, Results Both compatible granule and traditional decoction of Lizhongtang could effectively inhibit the intestine peristalsis, counterwork the cathartic role of Foliun Sennae, and decrease the velocity of gastric emptying, There was no notable difference on the first and second aspect between compatible granule and traditional decoction, but on the third one, compatible granule showed more effective than traditional decoction with the same dosage. Conclusion Lizhongtang compatible granule keeps and improves partially the effect of Lizhongtang traditional decoction.

关 键 词：理中汤 颗粒剂 汤剂 药效学 实验研究 

分 类 号：R285.5[医药卫生—中药学]