加替沙星阴道泡腾栓的药效学研究  

Pharmacodynamic Study of Gatifloxacin Vaginal Effervescent Suppository

作　　者：廖朝峰[1] 胡志军[1] 陈光龙[1] 

机构地区：[1]南方医科大学附属深圳宝安医院药剂科,广东深圳518101

出　　处：《中国药业》2006年第8期9-10,共2页China Pharmaceuticals

摘　　要：目的研究加替沙星阴道泡腾栓(GVES)的药效学。方法用3种常见致病菌感染豚鼠阴道,再用GVES治疗,治疗后评价药效,包括治疗后病原体转阴率和阴道病变治愈率。结果GVES低、中、高剂量(23.5,47.0,94.0mg/kg)阴道给药对金黄色葡萄球菌的转阴率分别为90.0%,100%,100%,对大肠杆菌的转阴率分别为95.0%,100%,100%,对淋球菌的转阴率分别为75.0%,95.0%,100%,总有效率分别为81.14%,88.00%,100%。总有效率与环丙沙星(85.71%)无显著性差异(P>0.05)。结论GVES对豚鼠致病菌阴道感染疗效明显。Objective To study the pharmacodynamics of gatifloxacin vaginal effervescent suppository （GVES） on the guinea pigs＋ Methods To infect on the guinea pig＇s vagina with 3 kinds of common bacteria. Then the guinea pigs were treated by GVES and evaluated for pharmacodynamics. The pharmacodynamic evaluation included bacterial eradication rates and cure rates after treatment. Results GVES was given to the guinea pig＇s through vagina by 23.5,47. 0, 94. 0mg/kg. The bacterial eradication rates were 90%, 100%, 100% for staphylococcus aurous; 95%, 100%, 100% for Escherichia coil; 75%, 95%, 100% for gonococcus,respectively. The overall efficacy rates were 81. 14%, 88. 00%,100% for GVES,85, 71% for ciprofloxacin vaginal suppository CVS as control,respectively（ P〉0. 05）, There was no significant difference. Conclusion GVES has obvious efficacy in the treatment of bacterial vaginal infection in guinea pigs,

关 键 词：加替沙星 阴道泡腾栓 细菌性阴道感染 药效学研究 

分 类 号：R965[医药卫生—药理学] R984[医药卫生—药学]