BAFF/APRIL系统研究进展  

Research Advance on the BAFF/APRIL System

作　　者：管政兵[1] 张双全[1] 

机构地区：[1]南京师范大学生命科学学院江苏省分子医学生物技术重点实验室,江苏南京210097

出　　处：《生物技术通讯》2006年第3期394-397,共4页Letters in Biotechnology

基　　金：国家自然科学基金项目(30271093)

摘　　要：BAFF和APRIL是新近发现的TNF配体超家族2个关系密切的成员。虽然它们共用2个受体BCMA和TACI,但转基因和基因敲除小鼠模型揭示它们各自功能并不冗余。BAFF是外周血B细胞一个关键的存活与成熟因子,它的活性通过其特异性受体BAFF-R调节,其过表达与自身免疫性疾病发生和B细胞肿瘤形成有关。APRIL在不依赖T细胞的Ⅱ型抗原反应和T细胞存活过程中扮演重要角色,同时它也能诱导一些非淋巴细胞的增殖和存活,在许多肿瘤细胞株和肿瘤组织文库中发现有高表达的APRIL。针对BAFF/APRIL系统设计出治疗相关疾病的生物制剂有着非常令人乐观的应用前景。BAFF and APRIL are two novel related members of the TNF ligand superfamily. Although they share two receptors, TACI and BCMA, transgenic and knockout mice in this system reveal that their functions are not redundant. BAFF is a critical survival/maturation factor for peripheral B cells and this activity is mediated through a BAFF-specific receptor, BAFF-R. Overexpression of BAFF has been linked to autoimmune disease and aspects of B cell neoplasia. APRIL plays an important role in T-independent type Ⅱ antigen responses and T cell survival, but can also induce proliferation/survival of non-lymphoid cells. Elevated expression of APRIL has been found in some tumor cell lines and in tumor tissue libraries. Genetically engineered pharmaceutics targeting the BAFF/APRIL system to protect against related diseases hold great promise for the future.

关 键 词：BAFF APRIL 体液免疫 自身免疫性疾病 肿瘤发生 

分 类 号：R392.11[医药卫生—免疫学]