阿维菌素的生物合成及代谢工程研究进展  

Biosynthesis and Metabolic Engineering of Avermectin

作　　者：田靖[1] 张惟材[1] 

机构地区：[1]军事医学科学院生物工程研究所,北京100071

出　　处：《生物技术通讯》2006年第3期447-450,共4页Letters in Biotechnology

摘　　要：阿维菌素(avermectin)是由除虫链霉菌(Streptomycesavermitilis)产生的一种具有杀虫活性的大环内酯类抗生素,在农业和畜牧业中应用广泛。本文综述了有关除虫链霉菌基因组序列分析、阿维菌素的生物合成以及阿维菌素育种和代谢工程的研究进展。Avermectin, produced by Streptomyces avermitlis, is a group of pentacyclic lactone antibiotics which have been widely used as antiparasitic drugs in veterinary and agricultural fields. In this review, the genome of Streptomyces avermitilis, biosynthesis pathway of avermectin, the method to obtain high avermectin producing strains, and the research progress achieved in metabolic engineering of Streptomyces avermitilis were discussed.

关 键 词：除虫链霉菌 阿维菌素 生物合成 代谢工程 

分 类 号：Q591[生物学—生物化学] S859.795[农业科学—临床兽医学]