十二烷基硫酸钠抗HSV1效应的研究  

Study of anti-herpes simplex virus type 1 effect of sodium dodecyl sulfate

作　　者：林有坤[1] 梁义[2] 梁铭[1] 刘剑勇[3] 张志明[2] 梁伶[1] 

机构地区：[1]广西医科大学第一附属医院皮肤性病科,南宁530021 [2]广西民族医院,南宁530023 [3]广西医科大学附属肿瘤医院,南宁530021

出　　处：《广西医学》2006年第5期630-633,共4页Guangxi Medical Journal

基　　金：广西壮族自治区自然科学基金资助项目(合同号:桂科自0135036)

摘　　要：目的为了证实十二烷基硫酸钠(Sodium Dodecyl Sulfate,SDS)抗HSV1的效应,初步确定其有效浓度与安全性。方法用体外细胞培养法观察不同浓度SDS对HSV1的抑制作用,同步进行ACV对照观察。结果SDS对HSV1的最低有效抑制浓度为0.015625mg mL,0.15625mg mL的SDS抑制作用与0.1mg mL阿昔洛韦组无明显差异(P>0.05);且最低有效抑制浓度的SDS对培养细胞的影响甚微,较此高8倍浓度的SDS仍然安全。结论SDS在体外对HSV1有明显抑制作用,对培养细胞的安全性好。Objective To confirm the suppressing effect of Sodium Dodecyl Sulfate to HSV- 1 and its effective concentration and security. Methods Cell culture was used to observe the suppressing effect of Sodium Dodecyl Sulfate to HSV-1 in different concentration. Retails It was showed that the lowest effective concentration for suppressing HSV-1 by Sodium Dodecyl Sulfate was 0.015 625 mg/mL, 0.156 25% SDS group was similar to 0.1% ACT group（ P 〉 0.05）. At this lowest effective concentration, sodium dodecyl sulfate had only tiny influence to Cell culture System,even when its concentration was 8 times of this lowest one. Conclusion Sodium dedecyl sulfate inhibits HSV-1 and has high security in cell culture.

关 键 词：十二烷基硫酸钠 HSV-1 细胞培养 

分 类 号：R113[医药卫生—公共卫生与预防医学]