氯乙酸溶剂法合成聚羟基乙酸  

Synthesis of Polyglycolide Acid from Chloroacetic Acid with Solvent

作　　者：于娟[1] 万涛[1] 李世普[1] 

机构地区：[1]武汉理工大学生物材料与工程研究中心,武汉430070

出　　处：《武汉理工大学学报》2006年第6期38-40,49,共4页Journal of Wuhan University of Technology

基　　金：国家重点基础研究发展计划(2005CB623905)

摘　　要：以氯乙酸为原料,在等物质的量浓度的三乙胺的作用下,溶剂为丙酮,加热温度为65℃,在冷凝回流的条件下进行反应,生成可降解聚合物聚羟基乙酸(PGA)。通过红外光谱、X射线衍射、差热分析等方法对合成的聚羟基乙酸进行表征,并在与乙醇酸直接缩合法和乙交酯开环聚合二步法等合成方法的比较中,得出氯乙酸溶剂法合成聚羟基乙酸的工艺流程短,操作简单,有利于降低合成PGA的成本。Starting from chIoroacetic acid, polyglycolide acid （PGA）, a biodegradable polymer material, can be synthesized via polymerization in presence of triethylarnine and acetone as the ,solvent at 65 12 in the condition of condensation and circumfluence. PGA was characterized by IR, DSC and X-ray diffraction. Compared with the direct contract-synthesize polymerization and the two-step synthesis method of ring opening polymerization, the chloroacetic acid with solvent polymerization had the advantages of short proceas, simple operation and time saving, which can reduce the production cost of PGA.

关 键 词：聚羟基乙酸 氯乙酸 乙醇酸 

分 类 号：TQ316[化学工程—高聚物工业]