Impact of automatic threshold capture on pulse generator longevity  

作　　者：CHEN Ruo-han CHEN Ke-ping WANG Fang-zheng HUA Wei ZHANG Shu 

机构地区：[1]Centre of Arrhythmia Diagnosis and Treatment, Fuwai Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China

出　　处：《Chinese Medical Journal》2006年第11期925-929,共5页中华医学杂志（英文版）

摘　　要：Background The automatic, threshold tracking, pacing algorithm developed by St.Jude Medical, verifies ventricular capture beat by beat by recognizing the evoked response following each pacemaker stimulus. This function was assumed to be not only energy saving but safe. This study estimated the extension in longevity obtained by AutoCapture （AC） compared with pacemakers programmed to manually optimized, nominal output. Methods Thirty-four patients who received the St. Jude Affinity series pacemaker were included in the study. The following measurements were taken： stimulation and sensing threshold, impedance of leads, evoked response and polarization signals by 3501 programmer during followup, battery current and battery impedance under different conditions. For longevity comparison, ventricular output was programmed under three different conditions： （1） AC on; （2） AC off with nominal output, and （3） AC off with pacing output set at twice the pacing threshold with a minimum of 2.0 V. Patients were divided into two groups： chronic threshold is higher or lower than 1 V. The efficacy of AC was evaluated. Results Current drain in the AC on group, AC off with optimized programming or nominal output was （14.33±2.84） mA, （16.74±2.75） mA and （18.4±2.44） mA, respectively （AC on or AC off with optimized programming vs. nominal output, P〈0.01）. Estimated longevity was significantly extended by AC on when compared with nominal setting [（103±27） months, （80±24） months, P〈0.01）. Furthermore, compared with the optimized programming, AC extends the longevity when the pacing threshold is higher than 1 V. Conclusion AC could significantly prolong pacemaker longevity; especially in the patient with high pacing threshold.Background The automatic, threshold tracking, pacing algorithm developed by St.Jude Medical, verifies ventricular capture beat by beat by recognizing the evoked response following each pacemaker stimulus. This function was assumed to be not only energy saving but safe. This study estimated the extension in longevity obtained by AutoCapture （AC） compared with pacemakers programmed to manually optimized, nominal output. Methods Thirty-four patients who received the St. Jude Affinity series pacemaker were included in the study. The following measurements were taken： stimulation and sensing threshold, impedance of leads, evoked response and polarization signals by 3501 programmer during followup, battery current and battery impedance under different conditions. For longevity comparison, ventricular output was programmed under three different conditions： （1） AC on; （2） AC off with nominal output, and （3） AC off with pacing output set at twice the pacing threshold with a minimum of 2.0 V. Patients were divided into two groups： chronic threshold is higher or lower than 1 V. The efficacy of AC was evaluated. Results Current drain in the AC on group, AC off with optimized programming or nominal output was （14.33±2.84） mA, （16.74±2.75） mA and （18.4±2.44） mA, respectively （AC on or AC off with optimized programming vs. nominal output, P〈0.01）. Estimated longevity was significantly extended by AC on when compared with nominal setting [（103±27） months, （80±24） months, P〈0.01）. Furthermore, compared with the optimized programming, AC extends the longevity when the pacing threshold is higher than 1 V. Conclusion AC could significantly prolong pacemaker longevity; especially in the patient with high pacing threshold.

关 键 词：AUTOCAPTURE current drain LONGEVITY pulse generator 

分 类 号：R197.39[医药卫生—卫生事业管理]