柴胡皂甙对戊四氮致痫大鼠的作用  

Study on the effect of saikosaponin on epilepetic rat induced by pentylenetetrazol

作　　者：于礼建[1] 谢炜[1] 谭红香[2] 

机构地区：[1]南方医科大学中医药学院内科教研室,广州510515 [2]广州市儿童医院神经康复科,广州510120

出　　处：《中药药理与临床》2006年第2期22-24,共3页Pharmacology and Clinics of Chinese Materia Medica

基　　金：广东省中医药管理局项目(No.401001;1040097)

摘　　要：目的:探讨柴胡皂甙对大鼠癫痫发作及脑电的影响。方法:观察柴胡皂甙对戊四氮致痫大鼠痫性发作潜伏期、发作程度以及脑电的影响。结果:腹腔注射柴胡皂甙50mg/kg、100mg/kg及150mg/kg三种剂量均能显著延长大鼠惊厥潜伏期,明显减轻大鼠痫样发作程度;对大鼠的脑电图有一定的改善作用。结论:柴胡皂甙具有抑制戊四氮诱发癫痫的作用。Objective： To explore the effect of saikosaponin on the acute seizure and electroencephalogram（EEG） of epileptic rat. Methods： The rat were used as the experimental object, the model of pentylenetetrazol（PTZ）-induced epilepsy was used, and the effect of saikosaponin on the seizure potential period and seizure level and EEG of epileptic rat were observed. Results： After the rat were injected intraperitoneally three kinds of dosage （50mg/kg, 100mg/kg, 150mg/kg） of saikosaponin, the seizure potential period were prolonged significantly and seizure level were relieved significantly, and the EEG of epileptic rat were improved in the 100mg/kg group. Conclusion： Saikosaponin can inhibit the epileptic seizure of PTZ-induced epilepsy.

关 键 词：柴胡皂甙 戊四氮 

分 类 号：R285.5[医药卫生—中药学]