以胶体粒子为模板制备含磁药物胶囊  

Fabrication of Magnetic Polyelectrolyte Dexorubicin Hydrochloride Capsules Templated on Colloidal Particles

作　　者：杨晓玲[1] 韩霄[1] 答鸿[2] 朱以华[1] 李春忠[1] 

机构地区：[1]华东理工大学材料科学与工程学院超细材料制备与应用教育部重点实验室,上海200237 [2]华东理工大学石油化工学院,上海201512

出　　处：《华东理工大学学报（自然科学版）》2006年第5期568-571,606,共5页Journal of East China University of Science and Technology

基　　金：国家自然科学基金资助(20276019;20236020);国家863计划资助(2002AA302208);上海市基础研究重大项目(04DZ14002);上海市纳米专项资助(0243nm069;0359nm001)

摘　　要：以低度交联的单分散三聚氰胺甲醛(M F)微球作为胶体模板,采用层层静电自组装技术,交替组装带正电的聚二烯丙基二甲基氯化铵(PDDA)和带负电的聚4-苯乙烯磺酸钠(PSS),得到具有核壳结构的复合微球,然后利用盐酸溶液将模板M F微球溶解,制得均匀的空腔胶囊。在N aC l浓度为0.7 m o l/L,pH<3时,将抗癌药物盐酸多柔米星(DOX)和磁流体同时封装到聚电解质胶囊中,可得到含磁药物胶囊,磁性粒子分散在胶囊的壳层和空腔内。该含磁药物胶囊具有良好的磁响应性和药物缓释性。Uniform hollow capsules were produced by layer-by-layer electrostatic self-assembly technique. The core-shell microspheres were constructed by alternately depositing negative and positive polyelectrolyte onto the weakly-crosslinked melamine formaldehyde （MF） microspheres which were used as the colloidal templates, then the templates were dissolved by 0. 1 mol/L hydrochloric acid and hollow capsules came into being. The anti-cancer drug dexorubicin hydrochloride （DOX） and magnetic fluid were encapsulate in the hollow capsules simultaneously in the 0. 7 mol/L NaCl solution at pH〈3 . Magnetic particles are dispersed in the wall and interior of capsules. The capsules loaded drug and magnetic particles have both good magnetic responsibility and controlled release property.

关 键 词：层层自组装 核壳式微球 含磁药物胶囊 载药 

分 类 号：TB322[一般工业技术—材料科学与工程]