冠心病介入治疗后肾上腺髓质素水平与再狭窄的关系  

Correlation between adrenomedullin in coronary circulation after PCI and restenosis

作　　者：刘海潮[1] 刘映峰[2] 李志樑[2] 唐朝枢[3] 

机构地区：[1]武汉华中科技大学同济医学院附属同济医院心内科,湖北武汉430030 [2]广州南方医科大学珠江医院心内科 [3]北京大学第一医院心血管病研究所

出　　处：《心血管康复医学杂志》2006年第3期216-218,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

基　　金：国家重点基础研究发展项目(973)子课题(G200056905)

摘　　要：目的:探讨冠心病患者行经皮冠脉介入治疗(PCI)术前、后冠脉循环中肾上腺髓质素(ADM)浓度变化与再狭窄的关系。方法:70例冠心病患者分别于术前,冠脉造影后、球囊扩张(PTCA)后、术后10 min采集冠状静脉窦血,同时采集股动脉血,采用放免法测定ADM及内皮素(ET)-1、肿瘤坏死因子(TNF)-α的浓度。术后6个月或有心肌缺血复发证据时复查冠状动脉造影。结果:随访结果显示,再狭窄发生率21．4％(15／70);与PCI术前比较,冠脉造影后冠脉循环中ADM、ET-1、TNF-α水平在有无再狭窄组无明显差异,球囊扩张后再狭窄组冠脉循环中ADM、ET-1、TNF-α含量明显多于无再狭窄组(P<0．01)。结论:球囊扩张后冠脉循环中ADM水平可作为预测PCI术后再狭窄的参考指标。Objective： To evaluate the correlation between adrenomedullin （ADM） in the coronary circulation in coronary heart disease （CHD） patients after percutaneous coronary intervention （PCI） and restenosis. Methods：Blood samples of 70 CHD patients were obtained from both the coronary sinus and femoral artery before and after angioplasty （immediately and 10 min）. Plasma ADM and ET-1, TNF-α levels were measured by radioimmunoassay, Coronary angiography （CAG） was performed again at 6 months after PCI or having evidences of myocardial ischemia. Results： Restenosis occurred in 21.4% （15/70） of patients. Before PCI, the ADM, ET-1, TNF-α levels in coronary sinus were no significant differences in patients with or without coronary restenosis. However, ADM, TNF-α levels after PTCA in 15 patients with restenosis were higher than those of without restenosis （P〈0. 01）. Conclusion： Result shows that ADM levels in coronary sinus after PTCA may a prognostic indicator of estimating restenosis.

关 键 词：肾上腺髓质素 血管成形术 经腔 经皮冠状动脉 冠状动脉再狭窄 

分 类 号：R541.4[医药卫生—心血管疾病]