心绞痛患者血浆醛固酮浓度变化的研究  

A study of serum aldosterone changes in angina

作　　者：吴大方[1] 周泉[1] 刘晓宇[1] 周岩[1] 刘秦原[1] 

机构地区：[1]解放军第451医院,陕西西安市710054

出　　处：《心血管康复医学杂志》2006年第3期230-231,共2页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:探讨醛固酮水平与心绞痛发生及预后的关系。方法:测定不稳定性心绞痛(UAP)及稳定性心绞痛 (SAP)患者血清醛固酮、肾素及血管紧张素水平,相互进行比较,并与健康对照组进行比较。结果:UAP组醛固酮水平明显高于健康对照组及SAP组(P<0．001),SAP组的又高于健康对照组(P<0．05)。醛固酮>427．4 pmol／ L时心脏事件的发生率(37．5％)明显高于≤427．4 pmol／L者(15．79％),P<0．01。结论:血清醛固酮水平可反映心绞痛严重程度,并有预后价值。Objective： To study the relationship between aldosterone changes and angina. Methods： Serum aldosterone, renin and angiotensin content were measured in 35 unstable angina pectoris （UAP） and 24 stable angina pectoris （SAP） and 30 healthy subjects. The diagnosis was based on the WHO criteria, and acute myocardial infarction （AMI） was rule out. The results were compared among groups. Results： Aldosterone levels were significantly higher in UAP patients than those of SAP and healthy control groups （P（0. 001）. The aldoaterone level of SAP group was higher than that of healthy control group （P（0.05）. Among the 60 UAP patients, the incidences of cardiac events. including AMI, sudden cardiac death and refractory angina pectoris were significantly higher in aldosterone〉427.4 pmol/L group than that in aldosterone≤427.4 pmol/L group （P〈0. 01）. Conclusion：The present study indicates that serum aldosterone level can demonstrates degree of angina and predict the prognosis of UAP patients.

关 键 词：心绞痛 醛固酮 预后 

分 类 号：R541.4[医药卫生—心血管疾病]