静脉用胺碘酮和毛花甙C转复阵发性房颤即时疗效对比  

Compare effects of intravenous amiodarone and cedilanid in the treatment of paroxysmal atrial fibrillation

作　　者：宋执敬[1] 王平[1] 李勇[1] 荆媛[1] 宋军[1] 任绪功[1] 

机构地区：[1]山东德州市人民医院心内科,山东德州253014

出　　处：《心血管康复医学杂志》2006年第3期250-252,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:比较静脉用胺碘酮和毛花甙C治疗阵发性房颤(PAF)的即时疗效和安全性。方法:84例发作时间在 24～72 h的PAF患者被随机分为胺碘酮组和毛花甙C组(每组42例),分别静脉内给予胺碘酮150～1180 mg和毛花甙C 0．4～0．8 mg。结果:胺碘酮和毛花甙C PAF转复率分别是83．3％和42．9％(P<0．01);未转复者的心室率在胺碘酮组由(128．4±12．3)降至(87．8±11．4)次／min(P<0．01),毛花甙C组由(129．6±13．1)降至(90．3± 11．9)次／min(P<0．01)。两组均无严重副作用发生。结论:静脉用胺碘酮治疗阵发性房颤有效且安全,其转复率显著高于毛花甙C。Objective ： To compare the acute efficacy and safety of intravenous amiodarone and cedilanid in the treatment of paroxysmal atrial fibrillation （PAF）. Methods： The 84 PAF patients which PAF duration was 24- 72 h were average divided into amiodarone group and cedilanid group. Amiodarone 150- 1180 mg and cedilanid 0. 4-0. 8 mg were given intravenously respectively. Results ：The rate of conversion to sinus rhythm was 83.3 % by amiodarone group and 42.9% by cedilanid group; its difference was significant （P〈0. 01）. The ventricular rate in no reverted patients were decreased from （128.4±12.3） to （87.8±11.4） times/min by amiodarone （P〈0. 01） and from （129.6±13.1） to （90. 3±11.9） times/min （P〈0.01） by cedilanid. No sever side effects were found in two groups. Conclusion： Intravenous amiodarone is effective and safe in the treatment of paroxysmal atrial fibrillation; its reverted rate is significantly higher than cedilanid.

关 键 词：胺碘酮 毛花甙C 心房颤动 

分 类 号：R541.75[医药卫生—心血管疾病]