卡维地洛并氯沙坦治疗慢性充血性心力衰竭的疗效  

Clinical efficacy of carvedilol combined with losartan on the treatment of congestive heart failure

作　　者：薛丽[1] 

机构地区：[1]新疆医科大学第一附属医院干一科,新疆乌鲁木齐830054

出　　处：《心血管康复医学杂志》2006年第3期252-254,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:探讨卡维地洛联合氯沙坦治疗慢性充血性心力衰竭(CHF)的临床疗效。方法:60例CHF患者随机单盲分成治疗组和对照组,治疗组给予氯沙坦50 mg／d,卡维地洛3．125 mg,1次／d,对照组给子氯沙坦及安慰剂治疗。两组基础治疗相同,疗程3个月。观察治疗前后两组患者的血压、心率、每搏量(SV)、心脏指数(CI)、左室射血分数(LVEF)、心输出量(CO)及不良反应。结果:治疗3个月后,治疗组心功能改善的临床显效率63．3％和总有效率96．7％均较对照组(30．0％和66．7％)显著提高(P<0．05)。与治疗前相比,治疗组治疗后血压、心率、LVEF、 SV、CI均有显著改善(P<0．01),与对照组比较差异亦有显著性意义(P<0．01)。结论:卡维地洛联合氯沙坦治疗 CHF可以增强疗效。Objective： To evaluate the clinical therapeutic efficacy of carvedilol combined with losartan on the treatment of congestive heart failure. Methods ： Sixty cases of CHF randomly received routine treatment （digitalis. diuretics, vasodilator, losartan）, but treatment group （30 cases） received carvedilol 3. 125 mg, 2 times/d and routine therapy. The clinical therapeutic efficacy, LVEF, SV and CI were analyzed. Results： The treatment efficiency of treatment group andcontrol group （30 cases） were 96.7% and 66.7% （P〈0. 05）. The improvements of HR, BP, SV and CI after treatment in treatment group were significant （P〈0. 01）. Their different between two groups was also significant （P〈0. 01）. Conclusion： Carvedilol combined with losartan have obvious effects on treating patient with CHF.

关 键 词：心力衰竭 充血性 卡维地络 氯沙坦 

分 类 号：R541.61[医药卫生—心血管疾病]