^(123)I-Annexin V在人体内的辐射吸收剂量估算  

Calculation of the internal radiation absorbed dose of ^(123)I-Annexin V

作　　者：靳彩玲[1] 许玉杰[1,2] 范我[1,2] 

机构地区：[1]苏州大学放射医学与公共卫生学院 [2]江苏省放射医学与防护重点实验室苏州215123

出　　处：《辐射研究与辐射工艺学报》2006年第3期175-177,共3页Journal of Radiation Research and Radiation Processing

基　　金：江苏省高校自然科学基金(04KJB350130);江苏省核医学与生物技术重点实验室开放基金(KJS01010)资助

摘　　要：为估算123I-AnnexinV在人体内的辐射吸收剂量并评价其安全性,用125I-AnnexinV作为示踪剂,测定放射性碘标记的AnnexinV在小鼠体内各脏器放射性分布并换算至标准人体内分布数据。按国际通用的由美国核医学会医学内照射吸收剂量委员会(Medicalinternalradiationdosecommittee,MIRD)提出的方法,将其输入Mirdose-3软件,估算人体内123I-AnnexinV辐射吸收剂量。实验结果表明,肝脏和肾脏是辐射吸收剂量最大的器官,其吸收剂量别为2.77×10-3mGy/MBq和2.71×10-3mGy/MBq,红骨髓内照射吸收剂量最低,约为1.78×10-5mGy/MBq,其它脏器的内照射吸收剂量在1.5×10-4mGy/MBq―10.5×10-4mGy/MBq之间,有效剂量当量(Effectivedoseequivalent,EDE)为5.55×10-4mSv/MBq。这为临床安全应用123I-AnnexinV提供了参考资料。To estimate absorbed doses by ^123I-AnnexinV in human, ^125I-AnnexinV was used as a radiotracer for measuring the distribution of radiolaheled Annexin V in mice. The standard Medical Internnal Radiation Dose （MIRD） method was used by Mirdose-3 software in dosimetry estimation. The results show that liver and kidney received 2.77×10^-3 and 2.71×10^-3 mGy/MBq, respectively. The red marrow received 1.78×10^-5 mGy/MBq, and the other organs received doses between 1.5×10^-4 and 10.5×10^-4mGy/MBq.The effective dose was estimated at 5.55×10^-4 mSv/MBq. Human radiation dosimetry can he performed by the mice hiodistrihution data and important data for clinical safe trial of ^123I-Annexin V are provided.

关 键 词：^123I-AnnexinV 小鼠 辐射吸收剂量 

分 类 号：R817.91[医药卫生—影像医学与核医学] R817.8[医药卫生—放射医学]