依达拉奉防治颅内动脉瘤术后迟发性脑血管痉挛的疗效观察  

Therapeutic effects of Edavavone for delayed cerebrovasacular spasm after intracranial aneurysm operation

作　　者：陈锐[1] 姜冰[1] 马建荣[1] 刘景平[1] 王君宇[1] 万新[1] 黄军[1] 董会晓[1] 兰松[1] 

机构地区：[1]中南大学湘雅医院神经外科,410008

出　　处：《临床神经外科杂志》2006年第2期57-59,共3页Journal of Clinical Neurosurgery

摘　　要：目的观察依达拉奉治疗颅内动脉瘤术后迟发性脑血管痉挛的疗效。方法60例脑动脉瘤术后患者随机分为治疗组和对照组,每组各30例。治疗组在常规治疗基础上加用依达拉奉注射液30mg,静滴,每日2次,14d后进行疗效评价。结果治疗组发生迟发性脑血管痉挛(DCVS)者仅2例,其发生率明显低于对照组(P<0.05);治疗组总有效率93.3%,而对照组为73.3%,两组比较有显著差异(P<0.05)。治疗组防治脑动脉瘤术后迟发性脑血管痉挛效果明显优于对照组。结论依达拉奉作为一种新型羟自由基清除剂,可以作为防治颅内动脉瘤术后迟发性脑血管痉挛有效的药物。Objective To evaluate the effects of treatment with Edavavone for delayed cerebrovascular spasm （DCVS） after intracranial aneurysm operation. Methods 60 cases with intracranial aneurysm were randomly divided into therapeutic group（ n = 30）and control group（ n = 30）. All patients were given the same treatment, but the dose of 30 mg edavavone twice a day for 14 days were given to the patients in treatment group. Rusuits There were 2 cases happened DCVS in therapeutic group,it was lower than that in the control group obviously （ P 〈 0.05 ） ; and the total effect rate in therapeutic group was 93.3% ,it was higher than that in control group significantly. Conclusions As a new hydroxy-free radical scavenger, Edavavone could become a valuable agent for the teatment of DCVS after intracranial aneurysm operation.

关 键 词：依达拉奉 羟自由基清除剂 迟发性脑血管痉挛 药物治疗 

分 类 号：R651.12[医药卫生—外科学]