湾鳄鳞甲提取物的抗肿瘤作用  

Study on the antitumor effect of extracts from scale and shell of Crocodylus porosus

作　　者：梅雪婷[1] 许东晖[1] 蒋次莲[1] 马海萍[1] 许实波[1] 

机构地区：[1]中山大学药学院中药与海洋药物研究室,广东广州510275

出　　处：《中国海洋药物》2006年第3期18-21,共4页Chinese Journal of Marine Drugs

基　　金：教育部2004年度"新世纪优秀人才支持计划"项目(NCET-04-0808);第9届霍英东教育基金会青年教师基金资助课题(No.91036)

摘　　要：目的研究湾鳄鳞甲提取物对小鼠肿瘤的抑制作用。方法用3%木瓜蛋白酶在60℃,pH7.0条件下降解湾鳄鳞甲14h,制备湾鳄鳞甲提取物。研究湾鳄鳞甲提取物对肝癌腹水型瘤株(HepA)和艾氏腹水型(EAC)瘤株的抗肿瘤作用。结果高剂量湾鳄鳞甲提取物(4.5g·kg-1)对HepA和EAC实体瘤小鼠的抑瘤率分别为30.01%(P<0.05)和37.69%(P<0.05);低剂量组(2.25g·kg-1)的抑瘤率分别为21.43%(P>0.05)和37.69%(P<0.01)。高剂量组湾鳄鳞甲提取物(4.5g·kg-1)对荷HepA和EAC小鼠的生命延长率为21.12%(P<0.05)和34.39%(P<0.05);低剂量组(2.25g·kg-1)对荷HepA和EAC小鼠的生命延长率分别为39.13%(P<0.01)和1.91%(P>0.05)。结论初步研究提示,湾鳄鳞甲提取物物对小鼠肿瘤有一定的抑制作用。Objective To study the inhibitory effects of the Crocodylus porosus extracts on murine tumor. Methods 3 % of papain was used to degrade the scale and shell of the Crocodylus porosus for 14 hours under 60℃ ,pH7.0. The effects of the extracts on hepatic solid tumor （HepA） and Ehrlich ascites carcinoma （EAC） were studied in mice. Results The inhibitory rates of the high-dose extract （4.5g·kg^-1） on HepA and EAC were 30.01%（P〈0.05）and 37.69（P〈0.05） respectively,and the inhibitory rates of the low-dose extract （2.25g·kg^-1）were 21.43%（PZ〉0.05）and 37.69% （P〈0.01）respectively. The high-dose extracts （4.5g·kg^-1） could prolong 21.12%（P〈0.05）and 34.39%（P〈0. 05）of the life span of HepA bearing mice and EAC bearing mice, and the low-dose （2.25g·kg^-1）were 39.13%（P〈0.01）and 1.91% （P〉0.05）respectively. Conclusion It is indicated by the primary research that the Crocodylus porosus extracts have inhibitory effects on the murine tumor.

关 键 词：湾鳄 鳞甲 提取物 抗肿瘤 

分 类 号：R979.1[医药卫生—药品]