抗白细胞介素-8单克隆抗体乳膏治疗寻常型银屑病的临床研究  

The effect and safety evaluation of an anti-IL-8 monoclonal antibody cream for the treatment of psoriasis vulgaris

作　　者：车敦发[1] 曹扬[1] 管海宏[1] 叶楠[1] 张敏[1] 金洁[2] 

机构地区：[1]南京军区南京总医院皮肤科,江苏南京210002 [2]南京军区南京总医院博士后科研工作站,江苏南京210002

出　　处：《医学研究生学报》2006年第6期548-550,共3页Journal of Medical Postgraduates

基　　金：江苏省"六大人才高峰重点课题"基金资助项目(批准号:2005A3)

摘　　要：目的:观察新型抗白介素-8单克隆抗体乳膏外用治疗银屑病的疗效和安全性。方法:选取84例寻常型银屑病患者外用抗白介素-8单克隆抗体乳膏治疗8周,观察不良反应及皮损大小、颜色、肥厚、鳞屑等变化,以判断安全性和疗效。结果:治疗8周后,11例基本痊愈,41例显著改善,痊愈率和有效率分别为13.1%和61.9%;其中点滴型的痊愈率和混合状的有效率最高,而进行期的痊愈率和有效率均高于静止期;其中只有1例出现轻度不良反应。结论:抗白介素-8单克隆抗体乳膏治疗寻常型银屑病有较好的临床疗效和安全性。Objective ： the treatment psoriasis To evaluate the effect and safety of an anti-IL-8 monoclonal antibody cream for vulgaris. Methods： Eight-four patients with psoriasis vulgaris were treated with the anti-IL-8 monoclonal antibody cream for 8 weeks, the safety and effect were evaluated by analyzing the adverse action and the changing After the treatments for 8 weeks, 11 of the diameter, color, thickness, scales of the lesions. Results： patients were cured, 41 patients were remarkably improved, the cure rate and effective rate is 13.1% and 61.9%, respectively. Among them the cure rate of guttate type and effective rate of mixed type were the highest, while the cure rate and effective rate for aggressive stage were both higher than those of stable stage. And only one patient had mild local adverse action. Con- clusion： The anti-IL-8 monoclonal antibody cream was effective and safe for the treatment of psoriasis vulgaris.

关 键 词：抗白细胞介素-8单克隆抗体 银屑病 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]