ErbBs受体在心脏发育和心肌病中的作用  

The Function of ErbBs in Heart Development and Myocardial Diseases

作　　者：彭健豪[1] 张连峰[1] 

机构地区：[1]中国医学科学院中国协和医科大学实验动物研究所,北京100021

出　　处：《中国比较医学杂志》2006年第6期376-378,共3页Chinese Journal of Comparative Medicine

摘　　要：ErbBs(ErbB1-4)属于酪氨酸激酶受体,可以传递表皮生长因子家族的信号。目前已知有4种亚型:ErbB1、ErbB2/HER2/neu、ErbB3及ErbB4。ErbBs信号系统在胚胎期心脏的发育过程中和维持成体心脏的功能方面都具有重要的作用。选择性ErbB2剔除的小鼠为研究ErbB2受体特异的抑制剂Trastuzumab所引起的扩张性心肌病和心力衰竭提供了动物模型,并揭示了ErbB2是ErbB3和ErbB4重要的辅助受体。在胚胎发育和成体心脏中ErbB2/4异源二聚体可以转导神经调节素信号,启动细胞内许多不同的信号传导途径,诸如ras/有丝分裂原激活的蛋白激酶、磷脂酰肌醇-3激酶/抗凋亡激酶、钙调蛋白依赖的激酶、p21激活的激酶-1及磷脂酶C途径,影响心脏的功能。The family of ErbB tyrosine kinase receptors can transmit signals derived from growth factor of epidermal growth factor family. There are four members in the ErbB tyrosine kinase receptor family： ErbB1, ErbB2/HER2/neu, ErbB3 and ErbB4. ErbBs play an essential role in the development of embryonic heart and maintaining cardiac function of adult heart. Conditional ErbB2 mutant mice provide an animal model for the major side effect, cardiomyopathy and heart failure, which can be observed in some patients undergoing chemotherapy with Trastuzumab and has revealed the important role of ErbB2 in normal heart function and ErbB2 function as an essential co-receptor of ErbB3 and ErbB4. Furthermore, ErbB2/4 heteromers transmit neuregnlin-1 signals in the developing and adult heart. ErbB receptors are known regulators of many signaling cascades, such as those involving ras/mitogen-activated protein kinase, phosphatidylinositol-3 kinase IAkt, phospholipase C and calcium -dependent kinase.

关 键 词：ERBB 扩张性心肌病 神经调节素 

分 类 号：R541[医药卫生—心血管疾病]