β-受体阻滞剂对老年慢性心力衰竭伴阵发性房颤患者P波最大时限及P波离散度的影响  

The effect of β-blocker on Pmax and Pd in chronic cardiac insufficiency patients with paroxysmal atrial fibrillation

作　　者：姜凤久[1] 冷沙沙[2] 任向阳 于海龙[4] 吴阳[1] 刘明[1] 

机构地区：[1]沈阳军区总医院综合一科,辽宁沈阳110016 [2]沈阳军区总医院北陵分院,辽宁沈阳110058 [3]总后驻沈阳干休所,辽宁沈阳110056 [4]辽宁省军区门诊部,辽宁沈阳110056

出　　处：《解放军保健医学杂志》2006年第2期81-82,共2页Journal Of Health Care And Medicine in Chinese Pla

摘　　要：目的探讨β-体阻滞剂对慢性心力衰竭伴阵发房颤患者P波最大时限（Pmax）及P波离散度（Pd）的影响。方法慢性心力衰竭伴阵发性房颤患者64例被随机分为美托洛尔治疗组（A组32例）和对照组（B组32例），慢性心力衰竭基本治疗两组相同，A组加用美托洛尔12．5～75mg／d，在治疗前、治疗后6个月、12个月分别测量Pmax和Pmin，计算出Pd（Pd=Pmax-Pmin）。结果治疗前两组Pmax和Pd比较无显著差异（P〉0．05）；治疗6个月、12个月A组的Pmax、Pd显著降低，与B组相同时间比较有非常显著意义（P〈0．01）；A组治疗前与治疗后6个月、12个月比较Pmax、Pd相差有显著意义（P〈0．01）；而B组间相差不显著（P〉0．05）。A组房颤发作次数明显减少，与B组比较差异有非常显著意义（P〈0．01）。结论β-体阻滞剂治疗慢性心力衰竭伴阵发性房颤患者可明显降低Pmax、Pd，减少房颤发作次数。Objective To investigate the effects of β-blocker on Pmax and P wave dispersion（Pd） in chronic cardiac insufficiency patients with paroxysmal atrial fibrillation（PAF）. Methods 64 patients were randomly divided into metoprolol treatment group（A group,n=32） and control group（B group, n= 32）. Basic treatment of chronic cardiac insufficiency in two groups was comparable. The patients（A group） were treated by metoprolol 12.5-75mg/d. Pmax and Pd were measured based on the 12-lead electrocardiogram at the beginning and at the six months,twelve months after taking medicine. Results At the beginning there was no significant difference between two groups （ P 〉 0. 05 ）;Pmax and Pd were significantly decreased in group A after 6 months, 12 months of treatment,compared to that of group B（ P 〈 0.01 ） ; the difference of Pmax and Pd was significant in A group between, before treatment and at the end of treatment（ P 〈 0.01 ）, but it was not significant in B group （ P 〉 0.05 ）. PAF rate was decreased after 6 months, 12 months of treatment. The difference was significant between two groups（ P 〈 0.01 ）. Conclusions Pmax and Pd were obviously decreased in chronic cardiac insufficiency patients with PAF. Metoprolol can decrease PAF rate by decreasing Pmax and Pd.

关 键 词：心力衰竭 心房颤动 P波离散度 Β-受体阻滞剂 

分 类 号：R541.7[医药卫生—心血管疾病]