氯沙坦对高血压病左心室重构的影响  

Effects of losartan on remodeling of left ventricle induced by hypertension

作　　者：张勇[1] 杜生明[1] 李斌儒[1] 曹元琪[1] 

机构地区：[1]兰州军区机关第二门诊部保健科,甘肃兰州730000

出　　处：《解放军保健医学杂志》2006年第2期95-96,共2页Journal Of Health Care And Medicine in Chinese Pla

摘　　要：目的评价血管紧张素Ⅱ受体拮抗剂氯沙坦对高血压病患者左心室重构的影响。方法148例原发性高血压患者应用氯沙坦50mg/d,疗程6个月,观察临床疗效,通过M型和多普勒超声心动图(UCG)观察对高血压病患者左心室重构的影响。结果治疗前后比较,SBP、DBP均明显降低,LVST、PWT明显降低,LVM和LVMI减轻(P<0.05)。结论长期服用氯沙坦可使原发性高血压患者的左心室重构发生逆转。Objective To assess the effects of angiotension Ⅱ （Ag Ⅱ ） receptor antagonist（losartan） on remodeling of left ventricle due to hypertension. Methods 148 cases that were all with mild to moderate primary hypertension co--existing left ventricular hypertrophy were treated with losarton, 50mg daily. Before treatment and after 6 months of therapy , the arterial pressure, the thickness of left ventricle walI（LVST） and the thickness of posterior wall（PWT） were determined. Results After 6 months of therapy, arterial pressure （SBP/DBP） and LVST/PWT were descended clearly （ P〈0. 05 ）. The left ventricle mass weight（LVM） and the left ventricle mass weight index（LVMI） were reduced clearly （ P〈 0.05 ）. Conclusions AgⅡ receptor antagonist can not only decreased the arterial pressure but also reverse reconstruction of the left ventricle.

关 键 词：高血压 左心室重构 氯沙坦 

分 类 号：R544.1[医药卫生—心血管疾病]