皮质下缺血性血管病的认知特征  

Cognitive profile of subcortical ischaemic vascular disease

作　　者：Jokinen H Kalska H MntylR. 樊慧婷 

机构地区：[1]Department of Neurology, Helsinki University Central Hospital, PO Box 302, FIN- 00029 HUS, Helsinki, Finland

出　　处：《世界核心医学期刊文摘（神经病学分册）》2006年第5期43-43,共1页Digest of the World Core Medical Journals:Clinical Neurology

摘　　要：Objectives: Subcortical ischaemic vascular disease (SIVD) is a subtype of vascular cognitive impairment characterised by extensive white matter lesions and multiple lacunar infarcts. Radiologically defined diagnostic criteria for SIVD have been introduced, but only a few studies have presented empirical data on its clinical and cognitive features. The aim of this study is to describe in detail the neuropsychological characteristics of patients with SIVD from a large well defined stroke cohort. Methods: A sample of 323 consecutive patients with ischaemic stroke, aged 55- 85 years, was investigated using neuropsychological examination and magnetic resonance imaging (MRI). Patients fulfilling the MRI criteria of SIVD (n = 85) were compared to the other stroke patients (n=238) and to normal control subjects (n = 38). Results: Cognitive performance of the SIVD group was inferior to that of the normal control group throughout all domains. As compared to the other stroke patients, the SIVD group performed significantly worse in tests measuring executive functions and delayed memory recall. Adjusting for depression had no effect on these results. Instead, after controlling for medial temporal lobe atrophy, the differences disappeared for delayed memory but remained significant for executive functions. Conclusion: Executive deficits are the most prominent cognitive characteristic associated with SIVD. Patients with SIVD also exhibit subtle deficits in delayed memory, which is explained in part by medial temporal lobe atrophy. Cognitive and mood changes seem to be parallel but independent processes related to SIVD. The results support the concept of SIVD as a separate clinical entity.Objectives： Subcortical ischaemic vascular disease （SiVD） is a subtype of vascular cognitive impairment characterised by extensive white matter lesions and multiple lacunar infarcts. Radiologically defined diagnostic criteria for SIVD have been introduced, but only a few studies have presented empirical data on its clinical and cognitive features. The aim of this study is to describe in detail the neuropsychological characteristics of patients with SIVD from a large well defined stroke cohort. Methods： A sample of 323 consecutive patients with ischaemic stroke, aged 55- 85 years, was investigated using neuropsychological examination and magnetic resonance imaging （MRI）. Patients fulfilling the MRI criteria of SIVD （n = 85） were compared to the other stroke patients （n = 238） and to normal control subjects （n = 38）. Results： Cognitive performance of the SIVD group was inferior to that of the normal control group throughout all domains.

关 键 词：缺血性血管病 认知特征 皮质下 血管性认知障碍 神经心理测试 卒中患者 神经心理学特征 SIVD 放射学诊断 MRI检查 

分 类 号：R651.15[医药卫生—外科学] R852.32[医药卫生—临床医学]