孕甾三醇的区域选择性乙酰化/溴代反应的研究  

Studies on the Regioselectivity of Acetylation-bromination in Pregnanetriol

作　　者：林静容[1] 王静[1] 陈丽君[1] 王玉春[1] 唐小枚[1] 许启海[2] 朱臻[2] 田伟生[1] 

机构地区：[1]上海师范大学生命与环境科学学院,上海200234 [2]中国科学院上海有机化学研究所,上海200032

出　　处：《化学学报》2006年第12期1265-1268,共4页Acta Chimica Sinica

基　　金：国家自然科学基金(Nos.29372077;20472052)资助项目.

摘　　要：为合理利用剑麻皂甙元资源,系统地考察了孕甾-3S,16S,20S-三醇和溴化氢/乙酸溶液的反应,并且发现了孕甾-3S,16S,20S-三醇的区域选择性乙酰化溴代反应,从而为转化孕甾-3S,16S,20S-三醇成为16R-溴代孕甾-3S,20S-二醇二乙酸酯提供了一个有效方法.In order to make rational utilization of tigogenin, the reaction of pregnane-3S,16S,2OS-triol and HBr/HOAc was explored in detail, and a regioselective acetylation-bromination reaction of pregnane-3S,16S,2OS-triol was found during this exploration. Based on this regioselective acetylation-bromination, pregnane-3S, 16S,20S-triol can be easily transformed into 16R-bromopregnane-3S,2OS-diol diacetate in good yield.

关 键 词：剑麻皂甙元 孕甾-3S 16S 20S-三醇 乙酰化溴代反应 

分 类 号：O621.25[理学—有机化学]