胰岛素强化治疗对重症肺炎早期血小板计数及血清CRP水平的影响研究  

作　　者：林玫瑞[1] 林少达[1] 张家芸[1] 许少明[1] 

机构地区：[1]汕头大学医学院第一附属医院ICU,广东汕头515041

出　　处：《中国民康医学》2006年第12期408-408,410,共2页Medical Journal of Chinese People’s Health

摘　　要：目的:研究细菌性重症肺炎患者早期施行胰岛素强化治疗对血小板计数及血清CRP水平的影响。方法:30例发生应激性高血糖(血糖超过9.0mmol/L)的细菌性重症肺炎患者配对后随机分为胰岛素强化治疗组和常规治疗组,连续检测7d血小板计数并监测C反应蛋白(CRP)变化以评估炎症强度。结果:胰岛素强化治疗显著降低了细菌性重症肺炎患者血清CRP水平,提高了PLT计数,与常规治疗组比较差异有显著性(P<0.05或P<0.01)。结论:胰岛素强化治疗可拮抗重症细菌性肺炎早期机体呈现的高炎状态,改善患者预后。Objective： To investigate the effect of intensive insulin therapy on serum levels of C reaction protein （CRP）and platelet count,all of which reflected the inflammatory status in patients with severe bacteroidal pneumonia. Methods：Thirty patients with severe bacteroidal pneumonia were randomly divided into intensive insulin therapy group and control group. Determine the CRP levels and platelet count within 7 days after admission.Remits： Serum levels of CRP in patients received intensive insulin therapy were significantly lower than those in patients without the therapy （ P 〈 0.05 or P 〈 0.01 ）. Platelet count in patients received intensive insuhn therapy were significantly higher than those in patients without the therapy（ P 〈 0.05 or P 〈 0.01 ）. Conclusions： Intensive insuhn therapy can attenuate the systemic inflammatory response to severe bacteroidal pneumonia. The anti - inflammatory actions of insulin, as well as its glycemia controlling effects, might contribute to the improved outcomes of patients with severe bacteroidal pneumonia.

关 键 词：重症肺炎 胰岛素强化治疗 C-反应蛋白(CRP) 血小板计数 

分 类 号：R977.15[医药卫生—药品] R563.1[医药卫生—药学]