丹参水溶性成分对中枢神经系统缺血缺氧的保护  

Study of the Protective Effects on the Ischemic and Anoxic Central Nerve System of Danshen's Hydrosoluble Compositions

作　　者：汤佩莲[1] 何飞武[2] 潘甜美[2] 

机构地区：[1]广东药学院门诊部,广东广州510224 [2]广东省医学实验动物中心,广东广州510180

出　　处：《河北医学》2006年第6期523-525,共3页Hebei Medicine

摘　　要：目的与方法:探讨丹参水溶性成分对中枢神经系统缺氧保护的作用和机理。以小鼠急性脑缺氧实验、耐化学性缺氧实验和全脑缺血动物模型三种不同的脑损伤方式,观察丹参水溶性成分对中枢神经系统缺血缺氧状态的影响。结果与结论:丹参水溶性成分能增加脑组织的耐缺氧能力、提高机体的血氧利用率,降低机体的耗氧量和降低自由基损伤等多个途径而实现对中枢神经系统的保护。Objective and Method： To study the effects and the mechanisms of Danshen＇ s hydrosoluble compositions on the ischemic and anoxic central nerve system.Experimental modles includes three means of injury on brain of mousesuffering from acute cerebral ischemia,mouse tolerant to ischemia reduced by chemical and global on the ischemic and anoxic central nerve system. Result and Conclusion： Danshen＇ s hydrosoluble compoatinos can improve the tolerence to anoxia of brain markedly,increase the utillty of oxygen in body blood decrease the oxygen consumption in organism,relieve the damage of free radicles and so on. By those means Danshen＇ s hydrosoluble compositions protect the central nerve system.

关 键 词：丹参水溶性成分 中枢神经系统 保护 

分 类 号：R285[医药卫生—中药学]