2型糖尿病患者血管并发症与血浆血管性血友病因子裂解酶的关系  

Relationship between Plasma vWF-cp Activity and Vascular Complications of Type 2 Diabetes Mellitus Patients

作　　者：郭小芳[1] 成兴波[1] 卢国元[1] 

机构地区：[1]苏州大学附属第一医院内分泌科,江苏苏州215006

出　　处：《苏州大学学报（医学版）》2006年第3期438-440,共3页Suzhou University Journal of Medical Science

基　　金：苏州大学211工程基金资助(No.2317175)

摘　　要：目的检测2型糖尿病患者血浆血管性血友病因子裂解酶(vWF-cp)活性,探讨其在糖尿病血管并发症中的意义。方法将74名2型糖尿病患者根据是否合并有血管并发症分为无并发症组(24例)、微血管并发症组(27例)、大血管并发症组(23例)。观察不同组患者血浆vWF-cp活性水平,并与正常对照组(40例)比较。结果2型糖尿病患者血浆vWF-cp活性水平明显低于正常对照组(P<0.05);合并大血管病变组vWF-cp水平明显低于其他糖尿病组(P<0.05)。结论血浆vWF-cp活性水平下降可能是2型糖尿病患者容易形成血栓的另一重要原因。vWF-cp活性异常可能在糖尿病的临床进展和并发症的发生中起重要作用。Objective To investigate the change of plasma von Willebrand factor cleaving protease （vWF-cp） activity level in patients with type 2 diabetes mellitus（T2DM） and to study its clinical significance in diabetes mellitus vascular complications. Methods Forty healthy subjects and 74 patients with type 2 diabetes mellitns were enrolled in this study. Plasma vWF-cp activity level was measured by residual-collagen binding assay（R-CBA）. Diabetes patients were further divided into three subgroups according to vascular complications： the group of 24 patients without complication, 27patients with microangiopathy, and 23 patients with macroangiopathy. Results The plasma vWF-cp activity level was significantly lower in patients with diabetes mellitus（DM） than that in the normal controls （P （0.05） ;The plasma vWF-cp activity level in the group of patients with macroangiopathy was significantly lower than that in the other two groups of patients with MD. Conclusion The change of plasma vWF-cp activity level maybe one of the reasons that patients with T2DM are prone to form thrombosis. The vWF-cp plays a important role in procedure of DM vascular complications.

关 键 词：2型糖尿病 血管并发症 血管性血友病因子 裂解酶 

分 类 号：R587.1[医药卫生—内分泌]