慢性肾功能衰竭患者尿转化生长因子β_1的检测及临床意义  

Detection of Urinary Transforming Growth Factor-β_1 in Patients with Chronic Renal Function Failure and Its Clinical Significance

作　　者：张冉[1] 熊佩华[1] 张玲[1] 陈爱平[1] 府剑英[1] 潘肇荣[1] 

机构地区：[1]苏州大学附属第一医院中西医结合科,江苏苏州215006

出　　处：《苏州大学学报（医学版）》2006年第3期450-452,共3页Suzhou University Journal of Medical Science

摘　　要：目的探讨尿TGF-β1在慢性肾功能衰竭(CRF)不同阶段的变化规律、作用及临床意义。方法采用ELISA方法测定60例不同阶段CRF患者和16例正常人尿TGF-β1水平。结果CRF患者尿TGF-β1高于正常人。Ⅰ、Ⅱ、Ⅲ期CRF患者尿TGF-β1随肾损害加重逐渐升高,而Ⅳ期CRF患者尿TGF-β1有下降趋势,与血清肌酐呈分离现象。结论CRF患者尿TGF-β1可作为反映肾损害程度的一个敏感性指标,有助于评价CRF的发生发展以及肾脏纤维化水平,同时对CRF的诊断和治疗具有指导意义。Objective To explore the role and the changing of TGF-β1 in different phase of Chronic Renal Function Failure（CRF） and to approach its clinical significance. Methods The urinary levels of TGF-β1 were examined by ELISA method in 60 patients with CRF, as well as 16 health controls were examined. Results The urinary levels of TGF-β1 in patients with CRF were higher than those in the healthy subjects. It stepped up gradually that the urinary levels of TGF-β1 in the phase of Ⅰ ,Ⅱ, Ⅲ in patients with CRF increased followed by the damage degree of kidney, The urinary levels of TGF-β1 in patients of phase Ⅳ CRF showed decreasing tendency. Conclusion The urinary levels of TGF-β1 in patients with CRF can become a sensitivity index to reflect the damage degree of kidney. It is helpful to appraise development of CRF and the level of fibrosis of kidney. Meanwhile there is significant to the guide diagnosis and treatment of patients with CRF.

关 键 词：慢性肾功能衰竭 转化生长因子Β1 肾纤维化 

分 类 号：R692.5[医药卫生—泌尿科学]