α-干扰素治疗小儿秋季腹泻60例疗效观察  

The effect of Interferon-α on children with autumn diarrhea

作　　者：曹爱国[1] 孙培[2] 荆友科 郝宁[1] 

机构地区：[1]淄博市第八人民医院儿科,淄博市255026 [2]滨州医学院护理系

出　　处：《滨州医学院学报》2006年第3期189-190,共2页Journal of Binzhou Medical University

摘　　要：目的 观察肌肉注射α-干扰素治疗小儿秋季腹泻的疗效.方法 将60例小儿秋季腹泻患儿随机分为两组,在常规治疗基础上,对照组30例经静脉滴注病毒唑;治疗组30例使用α-干扰素5万u/kg肌肉注射,每天1次,连用3～5 d.对两组临床疗效进行对比分析.结果 治疗组与对照组的治愈率分别为83.3%和56.7%,止泻时间分别为（2.20±0.80）d和（4.20±1.65）d,平均住院日分别为（5.20±1.10）d和（8.60±1.40）d,差异均有显著性（P＜0.05）.结论 α-干扰素治疗小儿秋季腹泻疗效好于病毒唑,缩短了患儿病程,可考虑临床应用.Objective To observe the therapeutic effect of Interferon-or （IFN-α） on children suffering from diarrhea. Methods 60 cases were randomly divided into control group（30 cases）and treated group（30 cases）. Based on the treatment with routine methods, ribavirin intra-venous-drip was used in control group,and IFN-α 50 000 u/kg intra-muscular injection was added in the treated group once a day for 3-5 days. Results The cure rate of the treated group was 83.3% ,which was higher than 56. 7% of the control group（x^2 = 5. 0794,P 〈 0. 05 ）. The time of stopping diarrhea of the treated group was （ 2. 20 ＋ 0. 80 ） d, which was shorter than （ 4. 20 ± 1.65 ） d of the control group（t＇= -5. 9739,P 〈0.05）. As well as the average hospitalization days of the treated group was（5.20± 1. 10） d, which was shorter than （ 8.60 ± 1.40 ） d of the control group （ t = 10. 4595, P 〈 0. 05 ）. Conclusions IFN-α has a better therapeutic effect in treating children with rotavirus diarrhea than ribavirin and shortens the course of disease, so it is worthy of clinical application.

关 键 词：Α-干扰素 轮状病素 腹泻 儿童 

分 类 号：R725.7[医药卫生—儿科]