线型和星型聚乙二醇-聚己酸内酯两亲嵌段共聚物聚集行为  

Aggregation Behavior of Linear and Star-Type Amphiphilic Poly(ethylene glycol)-Polycaprolactone Block Copolymers

作　　者：鲁成飞[1] 郭圣荣[1] 张亚琼[1] 姚炎庆[2] 

机构地区：[1]上海交通大学药学院,上海200240 [2]浙江理工大学材料与纺织学院,杭州310018

出　　处：《华东理工大学学报（自然科学版）》2006年第6期655-660,共6页Journal of East China University of Science and Technology

基　　金：国家973基础研究项目(2004CB518802);上海市科委纳米专项项目(0352nm106)

摘　　要：分别以单甲氧基聚乙二醇和4臂聚乙二醇引发己酸内酯开环聚合制得线型和星型聚乙二醇-聚己酸内酯(PEG-PCL)两亲嵌段共聚物。IR1、H-NMR和GPC测试结果表明所合成的共聚物具有预期的结构。该PEG-PCL两亲嵌段共聚物中PEG组分具有结晶性。共聚物在水相中自组装形成聚集体,聚集体的水合直径小于50 nm。高浓度共聚物在水性介质中会发生凝胶-溶胶转变,在凝胶-溶胶转变温度以下,共聚物形成凝胶网状结构。共聚物中PEG组分的结晶性、在水相中生成的聚集体的水合直径以及凝胶-溶胶转变行为均与聚合物的组成以及分子形状密切相关。Linear and star-type amphiphilic poly （ethylene glycol）-polycaprolactone （PEG-PCL） block copolymers were synthesized by ring-opening polymerization of ε-caprolactone using methoxyl poly （ethylene glycol） and 4-arm poly （ethylene glycol） as initiators, respectively, and characterized by means of IR, 1H-NMR and GPC. In the obtained copolymers, the PEG component is crystalline. The copolymers can be self-aggregated in water, the hydrodynamic diameters of the formed aggregations are below 25 nm. The gel-sol transition of copolymers in aqueous media can be observed. The aggregation behavior of the copolymers in air and aqueous media are related to copolymer compositions and architecture of the copolymer.

关 键 词：溶胶-凝胶转变 自聚集 结晶性 聚乙二醇-聚己酸内酯嵌段共聚物 

分 类 号：O636[理学—高分子化学]