双氯灭痛与苯醌类试剂荷移反应的研究  

Study on Charge Transfer Reaction of Diclofenac with Benzoquinones

作　　者：张升晖[1] 冯建章[1] 童沈阳[1] 

机构地区：[1]北京大学化学系

出　　处：《分析科学学报》1996年第3期194-197,共4页Journal of Analytical Science

基　　金：国家自然科学基金资助课题

摘　　要：本文研究了双氯灭痛与对苯醌和四氯苯醌之间的荷移反应．实验结果表明：双氯灭痛与对苯醌和四氯苯醌的反应分别在乙醇介质和弱碱性介质中进行．配合物的最大吸收波长分别是５１０ｎｍ和３３５ｎｍ；表观摩尔吸光系数分别是１．２９×１０３和１．１×１０４Ｌ·ｍｏｌ－１·ｃｍ－１；比尔定律的线性范围分别是１０～１２０μｇ／ｍＬ和２～３０μｇ／ｍＬ．The charge transfer interactions of Diclofenac with p benzoquinone and chloranil are investigated. In the ethanol medium the reaction of diclofenac with p benzoquinone occurs readily and the reaction between diclofenac with chloranil does in alkaline solution. The apparent molar absorptivity is 1.29×10 3 for p benzoquinone and 1.10×10 4 for chloranil. The products have absorption maximum at 510nm and 335nm respectively. The calibration graphs are linear over the concentration range of 10￣120μg/mL for p benzoquinone and 2￣30μg/mL for Chloranil. The proposed method was applied to the determination of diclofenac sodium tablets with satisfactory results.

关 键 词：电荷转移反应 苯醌 分光光度法 双氯灭痛 

分 类 号：R971.1[医药卫生—药品] O657.32[医药卫生—药学]