氯诺昔康自乳化释药系统处方优化的研究  

Formulation optimization of lornoxicam self-emulsifying drug delivery system

作　　者：李超[1] 张建军[1] 张钧寿[1] 

机构地区：[1]中国药科大学药剂学教研室,南京210009

出　　处：《中国药科大学学报》2006年第3期286-288,共3页Journal of China Pharmaceutical University

摘　　要：目的:优化氯诺昔康自乳化释药系统处方。方法:通过溶解度实验、正交筛选和相图绘制,以形成乳剂的乳化程度和乳化时间大小为指标,对氯诺昔康处方中的油相、非离子表面活性剂、助表面活性剂进行筛选,寻找最佳处方。结果:自乳化处方中油相为Lauroglicol FCC,非离子表面活性剂为Tween-85,助表面活性剂为Plurol Oleique,其最佳比例为5∶13∶2。结论:按优化处方制得的氯诺昔康自乳化释药系统大大提高了氯诺昔康在水中的溶解度。Aim： To perform the study on the formulation optimization of Lomoxicam self-emulsifying drug delivery system. Methods： Based on the degree of emulsification and emulsifying time, the fomaulation optimization （ i. e. , screening of suitable oil phases, nonionic surfactants and co-surfactants） was made by the use of determination of the solubility, orthogonal design and construction of tertiary phase diagram. Results. The experimental results reveals the optimized formulation of the self-emulsifying drug delivery system which consists of Lauroglycol FCC as oil phase, Tween-85 as nonionic surfactant, and Plural Oleique as co-surfactant in the proportion of 5 ： 13 ： 2. Conclusion： Application of the optimized formulation of Lomoxicam self-emulsifying drug delivery system could significantly increase the aqueous solubility of Lomoxicam.

关 键 词：氯诺昔康 自乳化释药系统 处方优化 

分 类 号：TQ460.1[化学工程—制药化工]