食用油加热产物的遗传毒性在伴性隐性致死试验中对不同生殖细胞阶段果蝇的影响(英文)  

The Genotoxic Effects of Products of Heated Edible Cooking Oil on Drosophila Melanogaster of Different Germ Cell Stages using Sex-linked Recessive Lethal Test

作　　者：厉曙光 陈科[3] 张辉[3] 王力强[3] 白莉华[3] 金泰廙[1] 

机构地区：[1]复旦大学公共卫生学院 [2]同济大学医学院,上海200092 [3]同济大学医学院

出　　处：《环境与职业医学》2006年第3期207-210,共4页Journal of Environmental and Occupational Medicine

基　　金：This work supported by grants from the National Natural Science Foundation of China (project number:30271123)

摘　　要：[目的]果蝇伴性隐性致死试验观察食用油烟雾(FEO)和食用油加热剩油(CEO)的致突变作用。[方法]分别用FEO(110、320、960μg/ml)和CEO(416、833、1667μg/ml)的3个不同浓度喂饲果蝇对其细胞的遗传毒性进行研究。[结果]320μg/ml浓度组的FEO第Ⅰ、Ⅱ、Ⅲ窝致突变率分别达到0.257%、0.530%和0.506%(P<0.001);110μg/ml浓度组的第Ⅰ窝和960μg/ml浓度组的第Ⅰ、Ⅱ窝与对照组相比差异有显著性(P<0.001)。所有CEO浓度组的伴性隐性致死试验结果都呈阳性(P<0.001),但未见剂量-反应关系。[结论]FEO和CEO对雄性黑腹果蝇具有较高的毒性作用。[ Objective ] To observe the effects of the fume of edible cooking oil （FEO） and the cooked edible oil （CEO） to induce mutation using a Sex-Linked Recessive Lethal Test （SLRL test） in Drosophila melanogaster. [ Methods ] Drosophila was fed with the CEO and FEO at three different concentrations as following： 416 μg/ml, 833 μg/ml and 1667 μg/ml for CEO; 110 μg/ml, 320 μg/ml and 960 μg/ml for FEO, respectively. [ Results ] The mutagene rates of FEO at 320 μg/ml concentration from firat brood to third brood were 0.257%, 0.530% and 0.506%, respectively, and there are same results that of the first brood at 110 μg/ml and the third brood at 320 μg/ml or 960 μg/ml compared with negative control （P 〈 0.001）. The results of CEO in all groups treated produced a positive response in SLRL test （P 〈 0.001） but there is no dose-response relationship among different groups. [ Conclusion ] Both of FEO and CEO have highly toxic effect on the male Drosophila melanogaster.

关 键 词：食用油烟雾 食用油加热剩油 果蝇 伴性隐性致死试验 

分 类 号：R114[医药卫生—卫生毒理学]