甜菜宁的最大无作用剂量  

Study on the Maximum Non - Effect Dose of Phenmedipham

作　　者：杨校华[1] 朱丽秋[1] 陈秀凤[1] 顾刘金[1] 陈琼姜[1] 朱勇[1] 徐娟[1] 黄雅丽[1] 孙建析[1] 吴立仁[1] 张幸[1] 

机构地区：[1]浙江省医学科学院,杭州市310013

出　　处：《职业与健康》2006年第13期961-963,共3页Occupation and Health

摘　　要：目的研究甜菜宁对大鼠的亚慢性毒性,求出最大无作用剂量。方法SD健康大鼠80只,随机分4组,每组20只,按照GB 15670-1995《农药登记毒理学试验方法》进行试验。结果5 000 mg／kg饲料组增重、食物利用率明显低于对照组,肺／体比、脾／体比、肝／体比高于对照组,15 000 mg／kg饲料组总摄食量、增重、食物利用率明显低于对照组,脑／体比、脾／体比、肝／体比、胸腺／体比高于对照组。病理组织学检查显示5 000、15 000 mg／kg饲料组肾、肺的病变率较高。结论甜菜宁的最大无作用剂量为雌性大鼠(133．06±13．11)mg/(kg·d),雄性大鼠(121．52±13．29)mg／(kg·d)。[ Objective ] To study the sub- chronic toxicity of Phenmedipham on rats and evaluate its maximum noneffect dose. [Methods]80 SD healthy rats were randomly divided into 4 groups; experiments were carried out according to the GB 15670- 1995 ＂ Toxicological Test Methods for Pesticides Registration＂. [ Results]Weight increase and food utility in the feedstuff group （ 5 000 mg/kg） were obviously lower than that of the control group; the lung- weight ratio, spleen- weight ratio and liver- weight ratio were all higher than that of the control group; the total amount of feedstuff intake, weight increase, food utility in the feedstuff group （ 15 000 mg/kg） were obviously lower than that of the control group, the brain- weight ratio, spleen- weight ratio, liver- weight ratio and thymus - weight ratio were all higher than that of the control group. The histopathological examination indicted that the rate of pathological changes in the kidney and lung of the feedstuff groups （5 000 and 1 500 mg/kg groups） was rather high. [ Conclusion ]The maximum non- effect dose of the Phenmedipham was （133.06± 13.11） mg/（kg·d） on female mrs and （121.52± 13.29） mg/（kg·d） on male rats.

关 键 词：甜菜宁 大鼠 最大无作用剂量 

分 类 号：R114[医药卫生—卫生毒理学]