杀菌剂十三吗啉的致突变性  

Mutagenicity of Pesticide Tridemorph

作　　者：陈琼姜[1] 顾刘金[1] 朱丽秋[1] 陈秀凤[1] 杨校华[1] 肖芸[1] 于仲波[1] 吴南翔[1] 

机构地区：[1]浙江省医学科学院,杭州市310013

出　　处：《职业与健康》2006年第14期1046-1047,共2页Occupation and Health

摘　　要：目的研究杀菌剂十三吗啉原药的致突变性。方法小鼠骨髓多染红细胞微核试验剂量设为150、3006、00 mg/kg;小鼠睾丸精母细胞染色体畸变试验剂量设为163、326、652 mg/kg。Ames试验剂量设为5、50、500、1 000、5 000μg/皿。结果小鼠骨髓多染红细胞微核试验和小鼠睾丸精母细胞染色体畸变试验,各剂量组和阴性对照组比较,差异无显著意义(P>0.05);Ames试验中各测试浓度的回变菌落数均末超过自然回变菌落数的2倍。结论该试验范围内,未见十三吗啉原药有致突变性。[ Objective] To study the mutagenicity of pesticide tridemorph. [ Methods] The marrow polychromatophilic erythrocyte micronucleus test on mice was processed by setting 3 different dose groups with 150,300 and 600 mg/kg respectively; the testis spermatocyte chromosome aberration test on mice was processed by setting 3 different dose groups with 1 63.1, 326.3 and 652.5 mg/kg respectively; Ames test was carried out by setting 5 different dose groups with 5, 50,500, 1 000 and 5 000 μg per plate respectively. [ Results] No significant difference was found between the dose groups and the control group in the marrow polychromatophilic erythrocyte micronucleus test and the testis spermatocyte chromosome aberration test （ P 〉 0.05 ） ; the mutated colonies of the dose groups were all less than twice of that of the control group. [ Conclusion] Within the range of the tests, no mutagenicity was found in the pesticide tridemorph.

关 键 词：十三吗啉 微核试验 精母细胞染色体畸变试验 AMES试验 致突变性 

分 类 号：R114[医药卫生—卫生毒理学]