激素替代治疗对生育期卵巢和宫颈恶性肿瘤患者血清降钙素的影响  

THE INFLUENCE OF HORMONE REPLACEMENT THERAPY ON SERUM CALCITONIN OF PATIENTS WITH OVARIAN OR CERVICAL CANCER AFTER SURGERY OR RADIOTHERAPY

作　　者：潘忠勉[1] 李力[1] 张玮[1] 陈心秋[1] 肖国有[1] 

机构地区：[1]广西医科大学附属肿瘤医院妇瘤科,南宁530021

出　　处：《广西医科大学学报》2006年第1期25-27,共3页Journal of Guangxi Medical University

基　　金：广西科技厅攻关课题资助(No.桂科攻9817101)

摘　　要：目的:探讨激素替代治疗(HRT)对生育期卵巢和宫颈恶性肿瘤患者外周血降钙素的影响。方法:生育期卵巢恶性肿瘤和子宫颈癌患者共158例,分别在手术或放疗前,手术患者在术后20d,放疗患者在盆腔放疗量达40Gy时,采用放射免疫法检测血清降钙素水平,此后将上述患者随机分为两组,一组使用倍美力片或尼尔雌醇片加安宫黄体酮片行HRT,另一组则为不用HRT组。对两组患者在半年至一年后再次检测血清降钙素含量。同时检测158例健康生育期妇女血清降钙素作为正常对照。结果:手术或放疗前生育期卵巢恶性肿瘤和宫颈癌患者血清降钙素水平与正常对照比较,差异无统计学意义(P>0·05);HRT组患者手术或放疗前血清降钙素水平与不用HRT组患者比较,差异亦无统计学意义(P>0·05)。但不用HRT组患者在手术或放疗后半年至一年后血清降钙素水平明显高于HRT组患者(P<0·05)。HRT组患者手术或放疗后半年至一年血清降钙素水平与手术或放疗前相比较,差异亦无统计学意义(P>0·05)。结论:生育期卵巢或宫颈恶性肿瘤患者手术或放疗后行HRT有助于保持血清降钙素水平的稳定,可能有利于降低生育期卵巢和宫颈恶性肿瘤患者卵巢“去势”后骨质疏松的发生。Objective： To explore the influence of hormone replacement therapy （HRT） on serum calcitonin of patients with ovarian or cervical cancer after surgery or radiotherapy. Methods： The level of serum calcitonin in 158 cases of ovarian or cervical cancer patients with or without HRT was detected by radio-immunity methods in pre-or post-surgery or radiotherapy after a half to one and half year respectively. The level of serum calcitonin in 158 cases of normal women was also tested as controls. Result：There was not difference between normal control and patents with ovarian or cervical cancer in pre-surgery or radiotherapy （ P 〉0.05）and there was also not difference between patients with or without HRT in pre-surgery or radiotherapy（ P 〉0.05）. The level of serum calcitonin in patients without HRT post-surgery or radiotherapy after a half to one and a half year was higher than that in pre-surgery or radiotherapy（ P 〈0.05）, but there was not significant difference between patients with HRT in post-surgery or radiotherapy after half to one and half year and in pre-surgery or radiotherapy. Conclusion： HRT for patients with ovarian or cervical cancer in post-surgery or radiotherapy helps to keep stable level of serums calcitonin and to improve osteoporosis.

关 键 词：卵巢恶性肿瘤 宫颈恶性肿瘤 激素替代治疗 降钙素 

分 类 号：R977.1[医药卫生—药品]