萘哌地尔衍生物BWYJ对大鼠膀胱内压和前列腺增生的作用  

Effect ofnaf topidil's ramification BWYJ on cystometry and benign prostatic hyperplasia in castrated rats

作　　者：于爽[1] 余丽梅[2] 吴芹[2] 石京山[2] 孙安盛[2] 袁牧[3] 

机构地区：[1]郑州大学医学院药理学教研室,450052 [2]遵义医学院药理学教研室 [3]贵州省中科院天然产物重点实验室

出　　处：《中国药物与临床》2006年第6期405-407,共3页Chinese Remedies & Clinics

基　　金：国家自然科学基金资助项目(30060087);贵州省科技基金重点资助项目(计[2002(3014)])

摘　　要：目的观察萘哌地尔衍生物BWYJ对大鼠前列腺重量及膀胱内压的影响。方法激素法诱发大鼠前列腺增生模型,称量并计算前列腺干重及干重指数,测定麻醉大鼠膀胱排尿阈值压及最大排尿压;观察BWYJ对兔离体膀胱颈平滑肌收缩反应的影响。结果BWYJ5、10、20mg/kg均可降低前列腺增生大鼠的前列腺干重指数(P<0.01),且可使膀胱排尿阈值压及最大排尿压均明显降低(P<0.01或P<0.05)。在离体兔膀胱颈平滑肌收缩实验中,BWYJ1×10-7mol/L使去氧肾上腺素所致平滑肌收缩的量效曲线平行右移,最大反应不变,拮抗参数(pA2)值为6.63。结论BWYJ有减轻前列腺重量及降低膀胱内压的作用,并提示可能与α1-肾上腺素能受体阻断作用有关。Objective To observe the effect of BWYJ on prostatic weight and bladder cystometry m castrated rats. Methods After castrated,SD rats were injected subcutaneously testosterone propionate to induce BPH.The prostatic dry weight was measured.The bladder maximum voiding pressure and threshold pressure were measured. Results BWYJ 5.10.20 mg/kg decreased the prostatic dry weight index of rat （P〈0.01）.BWYJ 5.10.20 mg/kg decreased threshold pressure and the maximum voiding pressure in anesthetized rats （P〈0.01 或 P〈0.05）.BWYJ 1×10^-7 mol/L caused paralled rightward shifts of the phenylephrine（Phe）concentration-contractile response curves and did not suppress the maximal contractile response to Phe （pA2=6.63）in isolated rabbit urinary bladder smooth muscle. Conclusion BWYJ can inhibite BPH and improve the urinary flow.

关 键 词：前列腺增生 肌细胞 平滑肌 膀胱 BWYJ 

分 类 号：R697.3[医药卫生—泌尿科学]