Graves病患者抑郁和焦虑状态及其脑血流量变化  

Analysis of depression and anxiety state and changes of regional cerebral blood flow in patients with Graves' disease

作　　者：于江媛[1] 李亚明[1] 尹雅芙[1] 李雪娜[1] 韩春起[1] 李德顺[1] 刘浩[1] 李娜[1] 梁晨荣[1] 孙振秋[1] 

机构地区：[1]中国医科大学附属第一医院核医学科,沈阳110001

出　　处：《中华核医学杂志》2006年第3期162-164,共3页Chinese Journal of Nuclear Medicine

摘　　要：目的探讨 Graves 病(GD)患者的精神状态、脑血流改变部位及两者之间的关系。方法对21例临床确诊为 GD 的右利手患者行 Zung 抑郁自评量表(SDS)、Zung 焦虑自评量表(SAS)评分及 SPECT 局部脑血流(rCBF)显像,判定 GD 患者抑郁和(或)焦虑程度及 rCBF 改变部位。结果病例组与对照组 SDS、SAS 评分差异有显著性(t 值分别为7.26、5.35,P 均<0.001)。90.5%(19/21例)的 GD 患者有抑郁和(或)焦虑症状,其严重程度与血清 FT_3、FT_4及 TSH 无关。SPECT 显像主要表现为额叶、颞叶、基底节及丘脑的放射性摄取减少,相应区域的 rCBF 降低百分比与 SDS、SAS 评分无关。结论 GD 患者伴随的精神症状较健康人群突出,其 rCBF 的降低多集中在双侧额叶、颞叶、基底节及丘脑。Objective To explore the incidence of depression and anxiety state and the changes of regional cerebral blood flow （rCBF） in patients with Graves＇ disease （GD）. Methods Twenty-one GD patients underwent rCBF SPECT imaging, and their mental state was evaluated by Zung self-rating depression scale（SDS） and Zung self-rating anxiety scale （SAS） respectively. Results Total scores obtained from SDS and SAS were both significantly greater in the GD group than that in the control group （tSDS = 7. 26, tSAS = 5.35 ,P 〈 0. 001 ）. 90.5% （ 19/21 ） of GD patients had symptoms of depression and （or） anxiety, but the severity was not correlative with FT3, FT4 and TSH levels. In SPECT imaging, GD group had decreased uptake of radioactivity in frontal lobs, temporal lobs, basal ganglia and thalamus mainly. There was also no significant correlation between the decrease of rCBF and SDS or SAS scores. Conclusions The psychiatric symptoms in GD group are more significant than normal controls, rCBF of GD group decreases mainly in bilateral frontal lobes, temporal lobes, basal ganglia and thalamus.

关 键 词：抑郁症 焦虑 格雷夫斯病 脑 局部血流 体层摄影术 发射型计算机 单光子 

分 类 号：R581[医药卫生—内分泌]