三种胰岛素给药方法治疗糖尿病酮症的疗效评价  

Effects of Three Methods of Insulin Treatment on Diabetic Ketosis

作　　者：欧小虹[1] 夏雪培 闫慧娴 

机构地区：[1]北京市海淀医院内分泌科,100080

出　　处：《天津医药》2006年第6期393-395,共3页Tianjin Medical Journal

摘　　要：目的:比较3种不同胰岛素给药方法对糖尿病酮症(DK)的治疗效果。方法:根据胰岛素治疗给药方法的不同,将78例糖尿病酮症患者分为3组,3组的年龄、入院血糖和体质量指数(BMI)差异均无统计学意义。A组(34例)采用微量泵静脉输入胰岛素治疗;B组(30例)皮下注射加小剂量胰岛素静脉滴注;C组(14例)用微量泵皮下注射胰岛素。统计纠正DK的时间、胰岛素总用量及相关指标。结果:(1)3组患者血β-羟丁酸经3种不同的胰岛素给药方法治疗后均降至正常,A组与C组的治疗时间均较B组缩短(P<0.01),A组与C组治疗时间差异无统计学意义。(2)尿酮体转阴时间A组与C组明显低于B组,差异有统计学意义(P<0.01)。(3)A组的治疗费用低于C组(P<0.01)。结论:微量泵静脉输入胰岛素治疗糖尿病酮症是一种既有效又经济的方法。Objective： To compare the effects of three methods of insulin treatment on diabetic ketosis （DK）. Methods： Seventy-eight DK patients were divided into three groups according to different insulin treatment method, including 34 patients treated with insulin by the intravenous micro-dosage pump in group A, 30 patients treated with insulin by hypodermic injection and intravenous low-dosage drip in group B and 14 patients treated with insulin by hypodermic micro-dosage pump in group C. There was no significant difference in age, blood glucose level and body weight index （BMI） among three groups. Correct DK time, total insulin dosage and related indexes were analyzed. Results： （1） Blood β-hydroxybutyrate acid levels restored to normal in three groups. Treatment periods of group A and group C were significantly shorter than that of group B （P 〈 0.01）. There was no significant difference between group A and group C in treatment period. （2） The turning-to-negative time of urinary ketone of group A and C were significantly shorter than that of group B. There was no significant difference between group A and group C. （3） Total treatment cost of group A was significantly lower than that of group C （P 〈 0.01）. Conclusion： Intravenous micro-dosage pump is an effective and economical method for patients with diabetic ketosis.

关 键 词：胰岛素 投药途径 胰岛素输注系统 糖尿病酮症 治疗结果 

分 类 号：R587.1[医药卫生—内分泌] R587.2[医药卫生—内科学]