GM-1PLGA微球的制备工艺优化研究  

Study on the Optimization of Preparation of GM-1 PLGA Microspheres

作　　者：蒋涛[1] 欧阳忠[1] 郭树章[1] 任先军[1] 

机构地区：[1]中国人民解放军第三军医大学附属新桥医院骨科,重庆400037

出　　处：《解放军药学学报》2006年第3期190-193,共4页Pharmaceutical Journal of Chinese People's Liberation Army

摘　　要：目的优化W/O/W型乳化溶剂挥发法制备GM-1PLGA微球的工艺。方法以载药量为检测指标,通过单因素分析和均匀设计法筛选影响微球制备工艺的10种因素,优化GM-1PLGA微球的制备工艺。结果在优化条件下制备的微球形态规则,粒径为(18.9±8.1)μm,载药量为4.91%,微球体外释药规律符合Higuchi方程:Q=0.153t1/2+0.03705,r=0.995。结论该制备工艺合理,为制备GM-1PLGA微球提供了理论依据。Aim To achieve the optimal method of preparation of GM-1 PLGA microspheres by w/o/w emulsion - solvent evaporation techniques. Methods The drug loading amount was used as the evaluating indicators to screen the 10 factors of preparation of GM-1 PLGA microspheres using single factor analysis and uniform - design method and to determine the optimal pareparetion condition. Results The shape of optimized microshperes was round, the integrated, particle size was （ 18.9 ＋ 8.1 ）tan, and the drug loading amount was 4.91%. The in vitro release profile agreed with Higuichi equation： Q = 0.153t^1/2 ＋ 0.037 05, （ r = 0.995）. Conclusions The researeh provided an optimal method for the preparation of GM-1 PLGA microspheres.

关 键 词：乳化溶剂挥发法 乳酸/羟基乙酸共聚物 微球 均匀设计 

分 类 号：TQ460.6[化学工程—制药化工]