甘草酸二铵与两种药物配伍后在不同输液中的稳定性研究  

Stability in Different Liquids of Glycyrrhizic Acid Diammonium Salt Mixing with 2 Kinds of Medicine

作　　者：熊汉申[1] 李小石[2] 燕兰英[1] 

机构地区：[1]江苏省南京市第二医院,江苏南京210003 [2]江苏省高淳县人民医院,江苏高淳211300

出　　处：《中国药业》2006年第6期11-12,共2页China Pharmaceuticals

摘　　要：目的考察甘草酸二铵(GA)注射液分别与注射用还原型谷胱甘肽、维生素K1注射液配伍后在5%葡萄糖注射液(GS)和5%木糖醇注射液中的稳定性。方法在恒温(25±1)℃条件下,用高效液相色谱法分析配伍液6h内的含量变化,同时观察外观、pH值、色谱峰变化。结果GA注射液与维生素K1注射液配伍后在5%GS中含量随时间推移略有下降,其他配伍液则无明显变化。结论GA注射液分别与注射用还原型谷胱甘肽、维生素K1注射液配伍后在5%木糖醇注射液中6h内性质稳定;GA注射液与注射用还原型谷胱甘肽配伍后在5%GS中6h内性质稳定,GA注射液与维生素K1注射液配伍后在5%GS内应尽快使用完。Objective To study the stability of glycyrrhizic acid diammonium salt injection mixing with reduced glutathione injection and vitamin K1 injection in 5% glucose injection and 5% xylitol injection. Methods The changes of content, which was determined by HPLC, were analyzed within 6 h at （25 ±1）℃; at the same time the changes of appearance, pH value and the peaks were observed. Results In glycyrrhizic acid diamonium salt mixing with vitamin K1 injection in 5% glucose injection, there was a small descent of content with the time changing, however, no significant changes were noted in other items. Conclusion The mixture of glycyrrhizic acid diammonium salt injection mixing with reduced glutathione injection and vitamin K1 injection in 5% xylitol injection is stable in quality within 6 h. The mixture of glycyrrhizic acid diammonium salt injection and reduced glutathione injection in 5% glucose injection is stable in quality within 6 h. The mixture of glycyrrhizic acid diammonium salt injection and vitamin K1 injection in 5% glucose injection will be used off quickly.

关 键 词：甘草酸二铵 还原型谷胱甘肽 维生素K1 稳定性 高效液相色谱法 

分 类 号：R969.2[医药卫生—药理学] R975.5[医药卫生—药学]