慢性乙型肝炎病毒感染中的甘露糖结合凝集素  

Mannose-binding lectin in chronic hepatitis B virus infection

作　　者：To Y.F. Ip W.K. Y.L. Lau 陈瑜 

机构地区：[1]Department of Paediatrics and Adolescent Medicine, Hong Kong Jockey Club Clinical Research Centre, University of Hong Kong, Pokfulam,HongKong,China

出　　处：《世界核心医学期刊文摘（胃肠病学分册）》2006年第5期43-43,共1页Core Journals in Gastroenterology

摘　　要：Mannose binding lectin (MBL) is a pattern-recognition molecule of the innate immune system. The roles of MBL and its gene (mbl2) polymorphisms,-221X/Y and codon 54A/B, in hepatitis B virus (HBV) infection were investigated in this study. We recruited 320 nonprogressed hepatitis B surface antigen (HBsAg) carriers; 199 progressed HBsAg carriers with hepatocellular carcinoma or cirrhosis; 87 spontaneously recovered individuals who were HBsAg negative and anti-HBs and anti HBc positive; and 484 controls who were na ve to HBV. There was no significant difference between nonprogressed carriers, spontaneously recovered individuals, and controls in terms of serum MBL levels and mbl2 polymorphisms distributions. However, the low MBL genotypes had a dose-dependent correlation with the cirrhosis and hepatocellular carcinoma in progressed carriers with odds ratios of 1.36 and 3.21 for the low and extremely low MBL genotypes, respectively (P = .01). The low-expression promoter haplotype XA (OR = 1.97) and the mutant haplotype YB (OR = 1.90) were also associated with the cirrhosis and hepatocellular carcinoma (P = .002). As expected, the lower serum MBL levels in progressed carriers as compared with nonprogressed carrierswere due to an over representation of lowand extremely low MBL genotypes. Moreover, MBL could bind HBsAg in a dose-and calcium-dependent and mannan-inhibitable manner in vitro, suggesting that binding occurs via the carbohydrate recognition domains. This binding also enhanced C4 deposition. In conclusion, these results suggest that low MBL genotypes associate with the occurrence of cirrhosis and hepatocellular carcinoma in progressed HBsAg carriers, and MBL can bind HBsAg.Mannose binding lectin （MBL） is a pattern-recognition molecule of the innate immune system. The roles of MBL and its gene （rob12） polymorphisms, - 221X/Y and codon 54A/B, in hepatitis B virus （HBV） infection were investigated in this study. We recruited 320 nonprogressed hepatitis B surface antigen （HBsAg） carriers; 199 progressed HBsAg carriers with hepatocellular carcinoma or cirrhosis; 87 spontaneously recovered individuals who were HBsAg negative and anfi-HBs and anti HBc positive; and 484 controls who were naYve to HBV. There was no significant difference between nonprogressed carriers, spontaneously recovered individuals, and controls in terms of serum MBL levels and mbl2 polymorphisms distributions. However, the low MBL genotypes had a dose-dependent correlation with the cirrhosis and hepatoeellular carcinoma in progressed carriers with odds ratios of 1.36 and 3.21 for the low and extremely low MBL genotypes, respectively （P = . 01）. The low-expression promoter haplotype XA （OR = 1.97） and the mutant haplotype YB （OR = 1.90） were also associated with the cirrhosis and hepatoceUular carcinoma （P = . 002） . As expected, the lower serum MBL levels in progressed carriers as compared with nonprogressed carrierswere due to an over representation of lowand extremely low MBL genotypes. Moreover, MBL could bind HBsAg in a dose- and calcium-dependent and mannan-inhibitable manner in vitro, suggesting that bind- ing occurs via the carbohydrate recognition domains.

关 键 词：慢性乙型肝炎病毒感染 甘露糖结合凝集素 乙型肝炎表面抗原(HBsAg) 乙型肝炎病毒(HBV) HBSAG携带者 MBL基因型 肝硬化患者 先天性免疫系统 携带HBSAG HBSAG阴性 

分 类 号：R512.62[医药卫生—内科学] R392.11[医药卫生—临床医学]