经皮微波与射频消蚀治疗肝细胞癌:一项回顾性比较研究  

Percutaneous microwave and radiofrequency ablation for hepatocellular carcinoma:A retrospective comparative study

作　　者：程妍 

机构地区：[1]M.-D. Lu, Department of Hepatobiliary Surgery, Sun Yat-Sen University, 58 Zhongshan Road 2, Guangzhou 510080, China

出　　处：《世界核心医学期刊文摘（胃肠病学分册）》2006年第5期47-48,共2页Core Journals in Gastroenterology

摘　　要：Abstract Abstract Background: Percutaneous microwave ablation and radiofrequency ablation are two commonly used modalities for the treatment of hepatocellular carcinoma; however, comparisons of them have not been documented adequately. Methods: Of 102 patients with biopsy-proved hepatocellular carcinoma, 49 (98 nodules) were treated percutaneously with microwave ablation and 53 (72 nodules) with radiofrequency ablation. The local tumor control, complications related to treatment, and long-term results of the two modalities were compared retrospectively. Results: The complete ablation rates were 94.9% (93/98) using microwave ablation vs 93.1% (67/72) using radiofrequency ablation (P = 0.75), and no significant differences were found either in the ablation of tumors of 3.0cm or less (P = 1.00) or in those of more than 3.0 cm (P = 1.00) between the two modalities. The local recurrence rates were 11.8% (11/93) using microwave ablation vs 20.9% (14/67) using radiofrequency ablation (P = 0.12), and there were no significant differences between the two modalities either in tumors of 3.0cm or less (P = 0.36) or in those of more than 3.0cm (P = 0.82). The rates of major complications associated with microwave ablation and radiofrequency ablation were 8.2% (4/49) vs 5.7% (3/53; P = 0.71). The disease-free survival rates in themicrowave ablation group were 45.9% , 26.9% , 26.9% , and 13.4% at 1, 2, 3, and 4 years, respectively, and those in the radiofrequency ablation group were 37.2% , 20.7% , and 15.5% at 1, 2 and 3 years, respectively (P = 0.53). The 1-, 2-, 3-, and 4-year cumulative survival rates for patients who underwent microwave ablation were 81.6% , 61.2% , 50.5% , and 36.8% , respectively, and for patients who underwent radiofrequency ablation the rates were 71.7% , 47.2% , 37.6% , and 24.2% , respectively (P = 0.12). Conclusions: Percutaneous microwave ablation and radiofrequency ablation are both effective methods in treating hepatocellular carcinomas. The local tumor control, complications related to treatmentBackground： Pereutaneous. microwave ablation and radiofrequency ablation are two commonly used modalities for the treatment of hepatocellular carcinoma; however, comparisons of them have not been documented adequately. Methods： Of 102 patients with biopsy-proved hepatocellular carcinoma, 49 （98 nodules） were treated pereutaneously with microwave ablation and 53 （72 nodules） with radiofrequency ablation. The local tumor control, complications related to treatment, and long-term results of the two modalities were compared retrospectively. Results： The complete ablation rates were 94. 9% （93/98） using microwave ablation vs 93. 1% （67/72） using radiofrequency ablation （P = 0. 75）, and no significitnt differences were found either in the ablation of tumors of 3.0cm or less （P = 1.00） or in those of more than 3.0 cm （P = 1.00） between the two modalities. The local recurrence rates were 11.8% （11/93） using microwave ablation vs 20. 9% （14/67） using radiofrequency ablation （P = 0. 12）, and there were no significant differences between the two modalities either in tumors of 3.0cm or less （P = 0. 36） or in those of more than 3.0cm （P = 0. 82）. The rates of major complications associated with microwave ablation and radiofrequency ablation were 8.2% （4/49） vs 5.7% （3/ 53; P = 0. 71）.

关 键 词：射频消蚀术 消蚀治疗 肝细胞癌 微波 经皮 回顾性 显著性差异 局部肿瘤 局部复发率 相关并发症 

分 类 号：R541.710.5[医药卫生—心血管疾病] R735.7[医药卫生—内科学]