4-甲基伞形酮衍生物的合成研究(II)  

Synthesis of 4-Methylumbelliferone Derivatives(II)

作　　者：照那斯图 叶红[1] 吴卫平 

机构地区：[1]浙江医药高等专科学校药学系,浙江宁波315100 [2]上海市食品药品管理局食品药品监督所,上海200031

出　　处：《化学世界》2006年第6期361-365,共5页Chemical World

基　　金：浙江省教育厅科研基金项目(20040001)

摘　　要：在乙腈溶剂中用聚乙二醇-400为相转移催化剂合成了8种4-甲基伞形酮衍生物,产率72%～89%.产物结构经IR、^1H NMR、^13C NMR及MS-EI进行表征.研究了影响反应的条件,温度为70～80℃,相转移催化剂为聚乙二醇-400,溶剂为乙腈.By using PEG-400 as phase transfer catalyst in presence of acetonitrile, eight 4-methyl umbelliferone derivatives were synthesized, and the yield was 72% - 89%. Their structure were characterized by IR, ^1 H NMR, ^13C NMR and MS-EI. The conditions of the reaction were investigated, and the optimum reaction termperature was 70 80℃, the best phase transfer catalyst was PEG-400 and the suitable solvent was acetonitrile.

关 键 词：4-甲基伞形酮 间苯二酚 乙酰乙酸乙酯 合成 

分 类 号：TQ244.2[化学工程—有机化工]