不同特性粘数壳聚糖降血浆胆固醇、甘油三酯及抗氧化活性研究  

Study on Reduction of Plasma TCH, TG and Antioxidation by Chitosan with Different Intrinsic Viscosity

作　　者：陈凡[1] 陈剑锋[1] 郭养浩[1] 张煜荣[1] 翁娜[1] 李国平[1] 

机构地区：[1]福州大学药物生物技术与工程研究所,福州350002

出　　处：《天然产物研究与开发》2006年第B06期23-25,共3页Natural Product Research and Development

基　　金：福州大学科技发展基金项目（2002-XY-10,XJB-0301,2003-QX-15）

摘　　要：通过醋酸-H2O2氧化降解法制备三种不同特性粘数（50℃时，η=4．76mL／g，29．39mL／g和54．93mL／g）的壳聚糖。以小鼠为实验对象，采取灌胃给药方式，考察其降低血浆TCH、TG的能力，并以血浆SOD酶活及MDA含量为指标，进行抗氧化药效学评价。结果显示，给药21d后，三种壳聚糖均能显著降低小鼠血浆TCH和TG含量，降幅分别大于28．2％和22．5％；且三种壳聚糖也能显著降低小鼠血浆MDA含量，降幅大于30．0％，但对小鼠血浆SOD酶活则无显著影响。Chitosan with different intrinsic viscosity such as 11=4.76 mL/g,29.39 mL/g and 54.93 mL/g at 50℃ were obtained using acetic acid-H2O2 degradation method. Rats were treated with these chitosan using ig method, the concentration of plasma TCH,TG and MDA were determined.The results showed：after 21 days,all three kinds of chitosan could Significantly reduce the TCH and TG level of rats＇ plasma mere than 28.2% and 22.5%, respectivdy. All three kinds of chitosan could significantly reduce the MDA level mere than 30.0% .And the rats＇ plasma SOD activity were not affected by the chitosan.

关 键 词：壳聚糖 特性粘数 降胆固醇 降甘油三酯 抗氧化 

分 类 号：R285[医药卫生—中药学]