慢性吗啡成瘾大鼠纳洛酮催瘾戒断后CPA模型的建立  

Developing the Condtitioned Place Aversion Rat Model Produced by Naloxone-Precipitated Withdrawal from Chronic Morphine Dependence

作　　者：李毅 郝伟[2] 王绪轶[2] 邓慧琼[2] 

机构地区：[1]华中科技大学同济医学院附属精神病院 [2]中南大学湘雅二医院精神卫生研究所,湖南长沙410011

出　　处：《中国临床心理学杂志》2006年第3期275-277,共3页Chinese Journal of Clinical Psychology

基　　金：国家973(项目号:2003CB515403);国家自然科学基金项目(项目号:30370522)资助

摘　　要：目的:建立稳定的吗啡依赖戒断后条件性位置厌恶(CPA)大鼠模型。方法:给予Sprague-Dawley(SD)大鼠吗啡10mg.kg-1,每天2次,腹腔注射(ip),连续6.5天,在吗啡注射第6天,予纳洛酮催瘾注射:0.3mg.kg-1,ip,1次,并与条件性位置反射训练箱搭配。结果:条件性搭配后,研究组试验鼠在伴药侧的时间显著性减少。结论:慢性吗啡注射纳洛酮催瘾戒断后CPA大鼠表现出明显厌恶动机,可作为研究阿片类物质戒断所致厌恶的生物学机制的载体。Objective： To develop the reliable conditioned place aversion （CPA） rat model bv naloxone-precipitated withdrawal from morphine-dependence. Methods： Naloxone （0.3mg.kg-1 intraperitoneally） was used to precipitate withdrawal symptoms in rats with morphin dependence （6.5d morphine injection. 10mg.kg-1 .intraperitoneally twice per day）. By pairing the precipitated withdrawal symptoms with the apparatus for place conditioning. CPA was developed in the rats. Results： During the CPA test session, the actual time of the rats in the MN group staying in the naloxone-paired compartment decreased significantly compared with that during the preconditioning session. Conclusion： The rats developed the CPA produced by naloxone-precipitated withdrawal from morphine dependence present obvious aversive motivation and would be used to study the biological mechanisms underlying the aversion due to opiates withdrawal.

关 键 词：条件性位置厌恶 吗啡 纳洛酮 依赖 催瘾戒断 

分 类 号：R395.1[哲学宗教—心理学]